- Additional Authors
- Description
- i, 6 pages : digital, PDF file
- Summary
- Pilots who are considered hypertensive are closely monitored by the Federal Aviation Administration (FAA) to ensure that their hypertension is properly controlled. During the investigation of fatal civil aviation accidents, postmortem samples obtained from pilots are submitted to the FAA's Civil Aerospace Medical Institute (CAMI) for toxicological evaluation. During such evaluation, submitted samples are analyzed for prescription and nonprescription drugs, and it is common to find beta-blocker antihypertensives such as atenolol, metoprolol, and propranolol in the submitted biological samples. During a 10-year period of 1993-2002, postmortem samples from 3290 civil aviation accident pilot fatalities (cases) were received by CAMI. Toxicological evaluation of these cases revealed that 50 of the 3290 fatalities had the commonly prescribed beta-blockers, atenolol, metoprolol, and propranolol. Out of the 50 fatalities, atenolol, metoprolol, and propranolol were found to be present in 24, 19, and 7 fatalities, respectively, but the initial analysis indicated the presence of atenolol and metoprolol in 4 of these pilot fatalities. Since (i) the combined use of both drugs was not consistent with the history of the drug use by those pilots, (ii) it is uncommon to simultaneously prescribe 2 beta-blockers, and (iii) these commonly used antihypertensives have considerable amount of chemical and structural similarity (6), further examination was undertaken for those fatality cases wherein atenolol and metoprolol were initially detected. Such examination entailed selectively and simultaneously analyzing the 3 commonly used beta-blockers in the submitted biological samples and rectifying any possible analytical interference with the antihypertensives.
- Subject
- Genre/Form
- Technical Report.
- Note
- Title from title screen (viewed on Nov. 20, 2008).
- "October 2004."
- "DOT/FAA/AM-04/15."
- Bibliography (note)
- Includes bibliographical references.
- System Details (note)
- Mode of access: Internet from the FAA web site. Address as of 11/20/08: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0415.pdf; current access available via PURL.
- Call Number
- GPO Internet TD 4.210:04/15
- OCLC
- marcive70713401
- Title
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol : final report / Mike K. Angier ... [and others].
- Publisher
Washington, DC : Office of Aerospace Medicine, U.S. Dept. of Transportation, Federal Aviation Administration ; Springfield, Va. : National Technical Information Service [distributor], [2004]
- Type of Content
text
- Type of Medium
computer
- Type of Carrier
online resource
- System Details
Mode of access: Internet from the FAA web site. Address as of 11/20/08: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0415.pdf; current access available via PURL.
- Bibliography
Includes bibliographical references.
- Funding
AM-B-04-TOX-204
- Connect to:
- Added Author
Angier, Mike K.
United States. Office of Aerospace Medicine.
- Other Form:
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol i, 6 p. (OCoLC)57317262
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol i, 6 p. (OCoLC)229180381
- Gpo Item No.
0431-E-04 (online)
- Sudoc No.
TD 4.210:04/15