Research Catalog

Title

Labelling of small biomolecules using novel technetium-99m cores.

Publication

Vienna, Austria : International Atomic Energy Agency, c2007.

Items in the Library & Off-site

Details

Additional Authors

International Atomic Energy Agency.

Description

309 p. : ill.; 24 cm.

Summary

Technetium-99m radiopharmaceuticals account for nearly 80% of all diagnostic studies done in nuclear medicine. The ability to determine the exact molecular structure of the coordination compounds by using modern powerful analytical tools such as NMR, mass spectroscopy and X ray diffraction has contributed to the understanding of the structure-activity relationships underlying the biological behavior of Tc-99m agents. Consequently, careful design of new ligands and their Tc-99m complexes led to the discovery of imaging agents for perfusion in the myocardium and brain, thereby extending the scope of diagnostic imaging using Tc-99m radiopharmaceuticals. Based on the new developments in Tc chemistry, there is good scope for the development of new radiopharmaceuticals for imaging cancer as well as certain specific disease conditions. The IAEA organized a Coordinated Research Project (CRP) with the specific objective to develop labelled biomolecules with the novel Tc-99m metal cores such as the Tc-99m-Carbonyl, Tc-99m-Nitrido, Tc-99m (4+1) and Tc-99m-HYNIC cores. The preparation, quality assessment and biological evaluations of a large number of Tc-99m complexes with biomolecules such as RGD peptides, annexin derived peptides, fatty acid derivatives, quinazoline derivatives and glucose analogues were achieved by the participants during the CRP. The results obtained from the participating laboratories are summarized in this publication.--Publisher's description.

Series Statement

Technical reports series / International Atomic Energy Agency ; 459

Uniform Title

Technical reports series (International Atomic Energy Agency) ; no. 459.

Subject

• Biomolecules
• Technetium
• Radiolabeling
• Radiopharmaceuticals

Note

• "STI/DOC/010/459"

Bibliography (note)

• Includes bibliographical references.

Additional Formats (note)

• Available both in print and online.

Contents

pt. 1. Overview of the coordinated research project -- pt. 2. Reports by the participants in the coordinated research project.

Call Number

JSE 09-60

ISBN

• 9201016077
• 9789201016072

OCLC

191954428

Title

Labelling of small biomolecules using novel technetium-99m cores.

Imprint

Vienna, Austria : International Atomic Energy Agency, c2007.

Series

Technical reports series / International Atomic Energy Agency ; 459

Technical reports series (International Atomic Energy Agency) ; no. 459.

Additional Formats

Available both in print and online.

Bibliography

Includes bibliographical references.

Connect to:

Connect to online resource

Added Author

International Atomic Energy Agency.

Research Call Number

JSE 09-60