- Description
- 1 online resource (xii, 143 pages) : illustrations.
- Summary
- Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter-ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented. Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution.--
- Uniform Title
- Acids and bases (Online)
- Alternative Title
- Acids and bases (Online)
- Subject
- Bibliography (note)
- Includes bibliographical references and index.
- Access (note)
- Access restricted to authorized users.
- Contents
- 1. Introduction -- 2. Acid-base equilibria: quantitative treatment -- 3. Solvation and acid-base strength -- 4. Determination of dissociation constants -- 5. Protic solvents -- 6. High-basicity polar aprotic solvents -- 7. low-basicity and low-polarity aprotic solvents -- 8. Acid-base equilibria and salt formation -- 9. Appendices: dissociation constants in methanol and aprotic solvents.
- LCCN
- 2012554149
- OCLC
- ssj0000970355
- Author
Cox, Brian G.
- Title
Acids and bases [electronic resource] : solvent effects on acid-base strength / Brian G. Cox, AstraZeneca Macclesfield, UK.
- Imprint
Oxford : Oxford University Press, 2013.
- Edition
First edition.
- Bibliography
Includes bibliographical references and index.
- Access
Access restricted to authorized users.
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