Research Catalog
The antibiotic era : reform, resistance, and the pursuit of a rational therapeutics
- Title
- The antibiotic era : reform, resistance, and the pursuit of a rational therapeutics / Scott H. Podolsky.
- Author
- Podolsky, Scott H.
- Publication
- Baltimore : Johns Hopkins University Press, [2015]
- Supplementary Content
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| Status | Format | Access | Call Number | Item Location |
|---|---|---|---|---|
Available - Can be used on site. Please visit New York Public Library - Schwarzman Building to submit a request in person. | Text | Use in library | JFE 16-13697 | Schwarzman Building - Main Reading Room 315 |
Details
- Description
- xii, 309 pages : illustrations; 24 cm
- Summary
- "In The Antibiotic Era, physician-historian Scott H. Podolsky narrates the far-reaching history of antibiotics, focusing particularly on reform efforts that attempted to fundamentally change how antibiotics are developed and prescribed. This sweeping chronicle reveals the struggles faced by crusading reformers from the 1940s onward as they advocated for a rational therapeutics at the crowded intersection of bugs and drugs, patients and doctors, industry and medical academia, and government and the media. During the postWorld War II "wonder drug" revolution, antibiotics were viewed as a panacea for mastering infectious disease. But from the beginning, critics raised concerns about irrational usage and overprescription. The first generation of antibiotic reformers focused on regulating the drug industry. The reforms they set in motion included the adoption of controlled clinical trials as the ultimate arbiters of therapeutic efficacy, the passage of the Kefauver-Harris amendments mandating proof of drug efficacy via well-controlled studies, and the empowering of the Food and Drug Administration to remove inefficacious drugs from the market. Despite such victories, no entity was empowered to rein in physicians who inappropriately prescribed, or overly prescribed, approved drugs. Now, in an era of emerging bugs and receding drugs, discussions of antibiotic resistance focus on the need to develop novel antibiotics and the need for more appropriate prescription practices in the face of pharmaceutical marketing, pressure from patients, and the structural constraints that impede rational delivery of antibiotics worldwide. Concerns about the enduring utility of antibioticsindeed, about a post-antibiotic eraare widespread, as evidenced by reports from the Centers for Disease Control and Prevention, academia, and popular media alike. Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward"--amazon.com.
- Subject
- Genre/Form
- History.
- Bibliography (note)
- Includes bibliographical references and index.
- Contents
- The Origins of Antibiotic Reform -- Antibiotics and the Invocation of the Controlled Clinical Trial -- From Sigmamycin to Panalba: Antibiotics and the FDA -- "Rational" Therapeutics and the Limits to Delimitation -- Responding to Antibiotic Resistance.
- Call Number
- JFE 16-13697
- ISBN
- 9781421415932
- 1421415933
- LCCN
- 2014014551
- OCLC
- 877024247
- Author
- Podolsky, Scott H., author.
- Title
- The antibiotic era : reform, resistance, and the pursuit of a rational therapeutics / Scott H. Podolsky.
- Publisher
- Baltimore : Johns Hopkins University Press, [2015]
- Type of Content
- text
- Type of Medium
- unmediated
- Type of Carrier
- volume
- Bibliography
- Includes bibliographical references and index.
- Local Note
- AUTH: HARVARD MEDICAL SCHOOL. FOCUSES ON ANTIBIOTIC REFORMERS SINCE 1940S.
- Connect to:
- Research Call Number
- JFE 16-13697