Research Catalog

Title

Cancer stem cells : philosophy and therapies / Lucie Laplane.

Author

Laplane, Lucie, 1984-

Publication

Cambridge, Massachusetts : Harvard University Press, 2016.

Items in the Library & Off-site

Details

Description

x, 252 pages : illustrations; 25 cm

Summary

"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher.

Subjects

• Stem cells
• Cancer > Treatment > Philosophy
• Oncology
• Cancer cells

Bibliography (note)

• Includes bibliographical references and index.

Contents

Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer?

Call Number

JFE 16-8446

ISBN

• 9780674088740
• 0674088743

LCCN

2015042054

OCLC

926061404

Author

Laplane, Lucie, 1984- author.

Title

Cancer stem cells : philosophy and therapies / Lucie Laplane.

Publisher

Cambridge, Massachusetts : Harvard University Press, 2016.

Type of Content

text

Type of Medium

unmediated

Type of Carrier

volume

Bibliography

Includes bibliographical references and index.

Research Call Number

JFE 16-8446