Research Catalog

Title

Prion diseases / edited by Stanley B. Prusiner.

Publication

• Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2017]
• ©2017

Items in the Library & Off-site

Details

Additional Authors

Prusiner, Stanley B., 1942-

Description

ix, 676 pages : illustrations (some color); 27 cm.

Summary

"Infectious proteins called prions are responsible for the devastating transmissible spongioform encephalopathy Creutzfeldt-Jakob disease. Prions are misfolded versions of proteins that replicate by converting their normal cellular counterparts into new prions and may play an important role in numerous other conditions, including Alzheimer and Parkinson's disease. Highlights include: Structural biology of PrP prions - Genetics of APP in Alzheimer's disease - Challenges of therapeutics for prion diseases and blood-brain barrier "--

Series Statement

Cold Spring Harbor perspectives in medicine

Uniform Title

Cold Spring Harbor perspectives in medicine.

Subject

• Prions
• Prion diseases
• SCIENCE > Molecular Biology
• MEDICAL > Diseases
• MEDICAL > Neuroscience

Bibliography (note)

• Includes bibliographical references and index.

Contents

Introcution: An Introduction to Prion diseases / Stanley B. Prusiner -- PrP: Prion Strain Diversity / Jason C. Bartz ; Biology and Genetics of Prp Prion Strains / Sina Ghaemmaghami ; Experimental Models of Inherited PrP Prion Diseases / Joel C. Watts and Stanley B. Prusiner ; Sporadic and Infectious Human Prion Diseases / Robert G. Will and James W. Ironside ; Molecular Mechanisms of Chronic Wasting Disease Prion Propagation / Julie A. Moreno and Glenn C. Telling ; Stuctural Biology of PrP Prions / Gerald Stubbs and Jan Stöhr -- TAU: Cellular Models for the Study of Prions / Brandon B. Holmes and Marc I. Diamond ; The Prion-Like Behavior of Assembled Tau in Transgenic Mice / Florence Clavaguera, Markus Tolnay, and Michel Goedert ; Interactions Between Microtubule-Binding Protein Tau (MAPT) and Small Molecules / Jennifer N. Rauch, Steven H. Olson, and Jason E. Gestwicki ; Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation? / Joshua Kriegel, Zachary Papadopoulos, and Ann C. McKee -- ASS: The Prion-Like Properties of Amyloid-ss Assemblies: Implications for Alzheimer's Disease / Lary C. Walker, Juliane Schelle, and Mathias Jucker ; SS-Amyloid Prions and the Pathobiology of Alzheimer's Disease / Joel C. Watts and Stanley B. Prusiner ; Genetics of SS-Amyloid Precursor Protein in Alzheimer's Disease / Julia TCW and Alison M. Goate ; Structural and Chemical Biology of Presenilin Complexes / Douglas S. Johnson, Yue-Ming Li, Martin Pettersson, and Peter H. St George-Hyslop ; Binding Sites for Amyloid-SS Oligomers and Synaptic Toxicity / Levi M. Smith and Stephen M. Strittmatter ; Molectural Structure of A-- Prion Properties of Aggregated Amyloid-SS: Insights from Solid State Nuclear Magnetic Resonance / Robert Tycko -- Alpha-SYNUCLEIN: Cell Biology and Pathophysiology of Alpha-Synuclein / Jacqueline Burré, Manu Sharma, and Thomas C. Südhof ; Alpha-Synuclein: Experimental Pathology / Masato Hasegawa, Takashi Nonaka, and Masami Masuda-Suzukake ; Alpha-Synuclein: Multiple System Atrophy Prions / Amanda L. Woerman, Joel C. Watts, Atsushi Aoyagi, Kurt Giles, Lefkos T. Middleton, and Stanley B. Prusiner ; The Transcellular Propagation and Intercellular Trafficking of a-Synuclein / George K. Tofaris, Michel Goedert, and Maria Grazia Spillantini ; Genetics of Synucleinopathies / Robert L. Nussbaum -- TDP-43, FUS, and C9ORF72: Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS) / Leslie I. Grad, Guy A. Rouleau, John Ravits, and Neil R. Cashman ; Genetics of Amyotrophic Lateral Sclerosis / Mehdi Ghasemi and Robert H. Brown, Jr. ; Biological Spectrum of Amyotrophic Lateral Sclerosis Prions -- Magdalini Polymenidou and Don W. Cleveland ; Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies / Lin Guo and James Shorter ; TDP-43 Prions / Takashi Nonaka and Masato Hasegawa ; Fused in Sarcoma Neuropathology in Neurodegenerative Disease / Ian R.A. Mackenzie and Manuela Neumann ; Disease Mechanisms of C9ORF72 Repeat Expansions / Tania F. Gendron and Leonard Petrocelli ; The Genetics of C9orf72 Expansions / Ilse Gijselinck, Marc Cruts, and Christine Van Broeckhoven -- Huntingtin and PolyQ: Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies / Maria Jimenez-Sanchez, Floriana Licitra, Benjamin R. Underwood, and David C. Rubinsztein ; Prion-Like Characteristics of Polyglutamine-Containing Proteins / Margaret M.P. Pearce and Ron R. Kopito -- Non-Central Nervous System Diseases: Prion-Like Protein Aggregates and Type 2 Diabetes / Abhisek Mukherjee and Claudio Soto ; Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission / Gunilla T. Westermark, Marcus Fändrich, Katarzyna Lundmark, and Per Westermark -- Therapeutics: Developing Therapeutics for PrP Prion Diases / Kurt Giles, Steven H. Olson, and Stanley B. Prusiner ; Insights from Therapeutic Studies for PrP Prion Disease / Kenta Teruya and Katsumi Doh-ura ; Antibody Therapeutics Targeting Ass and Tau / Gilbert Gallardo and David M. Holtzman ; Therapeutic Strategies for Restoring Tau Homeostasis / Zapporah T. Young, Sue Ann Mok, and Jason E. Gestwicki.

ISBN

• 9781621820109
• 1621820106
• 9781621822837
• 1621822834

LCCN

• 2016050453
• 99975990050
• 40027421037

OCLC

• ocn922914255
• 922914255
• SCSB-8996182

Owning Institutions

Columbia University Libraries