Research Catalog

Title

Principles of molecular virology / Alan J Cann.

Author

Cann, Alan.

Publication

San Diego, CA : Academic Press, 1993.

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Holdings

Details

Description

x, 234 pages : illustrations; 24 cm

Summary

• Provides an essential introduction to modern virology. Focussing on the new molecular approach, this textbook presents the principles of virology in a clear and concise manner that will give students of biology or medicine a broad, comprehensive understanding of the subject. The text explores and explains the fundamental aspects of virology including structure of virus particles and virus genomes, virus replication, control of gene expression, and virus pathogenesis (including AIDS).
• Later chapters consider the major current concerns in virology, such as responses to and treatment of virus infections, and the emergence of novel infectious agents including viruses, viroids and prions. The book is illustrated with over 100 clear line drawings, which complement the text. The summaries at the end of each chapter provide an excellent revision aid.

Subject

Molecular virology

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Ch. 1. Introduction. Viruses are distinct from 'living' organisms. The origins of virology. 'Molecular biology' -- Ch. 2. Particles. The function and formation of virus particles. Capsid symmetry and virus architecture. Enveloped viruses. Complex viruses. Protein-nucleic acid interactions and genome packaging. Virus receptors - recognition and binding. Other interactions of the virus capsid with the host cell -- Ch. 3. Genomes. The structure and complexity of virus genomes. Molecular genetics. Virus genetics. 'Large' DNA genomes. 'Small' DNA genomes. Positive-strand RNA viruses. Negative-strand RNA viruses. Segmented and multipartite virus genomes. Reverse transcription and transposition. Evolution and epidemiology -- Ch. 4. Replication. Overview of virus replication. Investigation of virus replication. The replication cycle -- Ch. 5. Expression. Expression of genetic information. Control of prokaryote gene expression. Control of expression in bacteriophage [lambda].
• Control of eukaryote gene expression. Genome coding strategies. Transcriptional control of expression. Post-transcriptional control of expression -- Ch. 6. Infection. Virus infections of plants. Immune responses to virus infections in animals. Virus-host interactions. The course of virus infections. Prevention and therapy of virus infections -- Ch. 7. Pathogenesis. Mechanisms of cellular injury. Viruses and immunodeficiency. Virus-related diseases. Cellular transformation by viruses. Viruses and cancer -- Ch. 8. Novel Infectious Agents. Emergent viruses. Satellites and viroids. Prions -- Appendix 1 Classification of Subcellular Infectious Agents -- Appendix 2 Glossary and Abbreviations.

ISBN

012158531X

OCLC

ocm29502487

Owning Institutions

Columbia University Libraries