Research Catalog

Title

An introduction to animal cytogenetics / H.C. Macgregor.

Author

Macgregor, Herbert C.

Publication

London ; New York : Chapman & Hall, 1993.

Items in the Library & Off-site

Holdings

Details

Description

xi, 238 pages : illustrations; 24 cm

Subjects

• Chromosomes
• Cytogenetics
• Animals > genetics
• Animals > Genetics

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Chromosomes in mitosis. The cell cycle. Chromosome numbers. Chromosome shape. Chromosome size. Chromosomes in mitosis. DNA per nucleus (C-value) -- 2. Karyology and evolution. Historical perspective. Chromosome banding. Karyotypes, genomes and evolution -- 3. Meiosis. Basic principles. Timing and sequence. The synaptonemal complex. Chromosome pairing. Chiasmata and crossing over. Disjunction. Duration of meiosis. Meiosis in rearranged chromosomes -- 4. Sex chromosomes and sex determination -- 5. Polyploidy in animals. The problems of becoming polyploid. Some specific examples. Evolving polyploidy -- 6. Inactivation and elimination of chromosomes. The Barr body. X inactivation in mice and mules. The timing of inactivation. The role of the second X. The genetic and molecular basis of inactivation. Inactivation and imprinting. More about insects. Ascaris and chromatin elimination. The protozoan macronucleus -- 7. DNA replication, endomitosis and trophic polyploidy.
• The semiconservative replication of chromosomes. The principles of trophic polyploidy. Some examples of polyploid cells. Polytene chromosomes. Selective DNA replication -- 8. The nucleolus organizer and gene amplification. Basic molecular biology. Identifying nucleolus organizers. Rings, Christmas trees and transcription units. Understanding amplification. Variation and evolution. The activity of nucleolus organizers -- 9. Lampbrush chromosomes. History and technology. Basic organization. Two famous hypotheses. Lampbrushes under the electron microscope. In situ hybridization. The read-through hypothesis. Three simple experiments with enzymes. Some more questions about lampbrushes -- 10. DNA sequences and genome evolution. The classification of DNA sequences. Variation in repeat sequence DNA. Agents of change. Sister chromatid exchange. What keeps genomes in check? The story of a liberated chromosome -- 11. Human clinical cytogenetics. Conventions for describing human chromosomes.
• The problem of aneuploidy. Trisomy 21 and Down's syndrome. Monosomy X. The clinical cytogenetics laboratory -- 12. Outlook for 2001 -- Appendix: A selection of laboratory practical protocols.

ISBN

0412546000 (alk. paper)

LCCN

93013470

OCLC

ocm28024127

Owning Institutions

Columbia University Libraries