Research Catalog

Title

Growth factors : a practical approach / edited by Ian McKay and Irene Leigh.

Publication

Oxford ; New York : IRL Press at Oxford University Press, [1993], ©1993.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• McKay, Ian (Ian A.)
• Leigh, Irene (Irene M.)

Description

xx, 251 pages : illustrations; 24 cm.

Summary

• There has been a major expansion of interest in growth factors reflecting their very important role in the regulation of the proliferation and differentiation of specific cell types. A large number of growth factors have already been identified but this probably represents only a fraction of all those that exist.
• This book is a step-by-step guide to studying growth factors, from the initial search for and characterization of new activities, to sophisticated in vivo analysis and molecular biology approaches such as DNA cloning. It also covers the detection and study of growth inhibitory factors. Growth Factors: A Practical Approach is an invaluable practical guide for both those entering growth factor research for the first time and more experienced researchers.
• As well as covering a wide variety of techniques, this book includes a valuable appendix covering all known growth factors.

Series Statement

Practical approach series ; 119

Uniform Title

Practical approach series ; 119.

Subject

• Growth factors > Methodology
• Growth Substances
• Structure

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Types of growth factor activity: detection and characterization of new growth factor activities / I. A. McKay -- 2. Detection of polypeptide growth factors: application of specific bio-assays and PCR technology / E. J. J. Van Zoelen, B. Delaey, B. Van der Burg and D. Huylebroeck -- 3. Induction of DNA synthesis and cell division in quiescent cells in response to small peptide growth factors / Anthony N. Corps and Kenneth D. Brown -- 4. Novel gene transcription in response to growth factors: gene isolation by differential plaque hybridization / P. Sanjeeva Reddy and Brent H. Cochran -- 5. Embryological assays for growth factors / J. M. W. Slack -- 6. The role of TGF-[beta] in bone growth and bone repair / R. T. Ballock and A. B. Roberts -- 7. Localization of growth factor mRNA in tissue sections by in situ hybridization / Rosemary J. Akhurst -- 8. Detection and characterization of growth inhibitory factors: epidermal inhibitory pentapeptide (EIP) / Philip Robinson, Paul Whitehead and William Hume.
• 9. Expression of growth factors in microbial systems / Timothy J. Dudgeon, John M. Clements and Michael G. Hunter -- 10. Immunoassays for growth factors / Stephen J. Capper -- 11. Determination of growth factor receptor distribution by immunocytochemistry or autoradiography, and quantitation by ligand binding or FACS analysis / Claire Linge and Martin R. Green -- App. A1 Growth factors -- App. A2 Sources of cell strains and cell lines -- App. A3 Amino acid abbreviations -- App. A4 Names and addresses of suppliers.

ISBN

• 0199633606 (hbk.) :
• 0199633592 (pbk.) :

LCCN

92027317

OCLC

ocm26764626

Owning Institutions

Columbia University Libraries