Research Catalog

Title

Overexpression and knockout of cytokines in transgenic mice / edited by Chaim O. Jacob.

Publication

London ; San Diego : Academic Press : Harcourt Brace & Co. Publishers, [1994], ©1994.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Jacob, Chaim O.

Description

xiii, 191 pages : illustrations; 24 cm

Summary

• Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vivo'.
• The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions.
• Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances.

Subject

• Genetic Engineering
• Cytokines
• Immunity, Cellular

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Introduction / C. O. Jacob -- 1. Strategies for modulation of interleukin-1 in vivo: knockout and transgenics / F. F. Csaikl, U. M. Csaikl and S. K. Durum -- 2. In situ production of interleukin-2 and its role in autoimmunity / J. Allison, W. R. Heath and J. F. A. P. Miller -- 3. Interleukin-2 overexpression and deprivation: consequences for lymphopoiesis and T cell function / A. Schimpl and T. Hunig -- 4. Interleukin-4 expressing transgenic mice: in vivo models for studying the actions of a cytokine / H. J. Burstein, R. I. Tepper and A. K. Abbas -- 5. Interleukin-5 activity in vivo / C. J. Sanderson and M. Strath -- 6. Interleukin-6 transgenic mouse: a model of chronic inflammatory proliferative disease / T. Hirano -- 7. Leukemia inhibitory factor and mammalian development / C. L. Stewart -- 8. Lymphopoiesis in mice homozygous for an interleukin-7 transgene: in vivo interactions with abnormal interleukin-4 or c-Kit receptor expression / R. Palacios and J. Samaridis.
• 9. Expression and knockout of interferons in transgenic mice / C. O. Jacob -- 10. Human erythropoietin gene expression in transgenic mice / G. L. Semenza -- 11. The importance of transforming growth factor-[beta]1 in immunological homeostasis as revealed by gene ablation in mice / M. M. Shull, A. B. Kier, R. J. Diebold, M. Yin and T. Doetschman -- 12. Granulocyte-macrophage colony stimulating factor transgenic mice / D. Metcalf.

ISBN

0123784506

OCLC

ocm31191307

Owning Institutions

Columbia University Libraries