Research Catalog

Retroviral proteases

Title
Retroviral proteases / edited by Lawrence C. Kuo, Jules A. Shafer.
Publication
San Diego : Academic Press, [1994], ©1994.

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Details

Additional Authors
  • Kuo, Lawrence C.
  • Shafer, Jules A.
Description
xxv, 432 pages : illustrations (some color); 24 cm.
Series Statement
Methods in enzymology, 0076-6879 ; v. 241
Uniform Title
Methods in enzymology ; v. 241.
Subject
  • Proteolytic enzymes
  • Retroviruses > Enzymes
  • HIV (Viruses)
  • Protease Inhibitors
  • Retroviridae Proteins
Bibliography (note)
  • Includes bibliographical references and indexes.
Contents
  • 1. Expression Systems for Retroviral Proteases / Jeffrey Stebbins and Christine Debouck -- 2. Genetic Approaches Designed to Minimize Cytotoxicity of Retroviral Protease / C. J. Rizzo and B. D. Korant -- 3. Host Strain Selection for Bacterial Expression of Toxic Proteins / Elizabeth Chen -- 4. Assay Methods for Retroviral Proteases / Christopher U. T. Hellen -- 5. Analysis of Human Immunodeficiency Virus Type 1 Protease Activity in Eukaryotic and Bacterial Cells / Andrew H. Kaplan, Marianne Manchester, Lorraine Everitt and Ronald Swanstrom -- 6. Synthetic Approaches to Continuous Assays of Retroviral Proteases / Grant A. Krafft and Gary T. Wang -- 7. Identification, Purification, and Cell Culture Assays of Retroviral Proteases / Klaus von der Helm, Sigrio Seelmeier, Alexei Kisselev and Hans Nitschko -- 8. Stability of Dimeric Retroviral Proteases / Paul L. Darke.
  • 9. Use of Steady State Kinetic Methods to Elucidate the Kinetic and Chemical Mechanisms of Retroviral Proteases / Thomas D. Meek, Evelyn J. Rodriguez and Thelma S. Angeles -- 10. X-Ray Structures of Retroviral Proteases and Their Inhibitor-Bound Complexes / Dagmar Ringe -- 11. Probing Structure-Function Relationships in Human Immunodeficiency Virus Type 1 Protease via Molecular Dynamics Simulation / William E. Harte, Jr. and David L. Beveridge -- 12. Relationships of Human Immunodeficiency Virus Protease with Eukaryotic Aspartic Proteases / Xin-Li Lin, Ying-Zhang Lin and Jordan Tang -- 13. Processing of Retroviral Gag Polyproteins: An in Vitro Approach / Carol Carter and Gabriele Zybarth -- 14. Subsite Preferences of Retroviral Proteinases / Ben M. Dunn, Alla Gustchina, Alexander Wlodawer and John Kay -- 15. Specificity of Retroviral Proteases: An Analysis of Viral and Nonviral Protein Substrates / Alfredo G. Tomasselli and Robert L. Heinrikson.
  • 16. Rapid Determination of Endoprotease Specificity Using Peptide Mixtures and Edman Degradation Analysis / Frank R. Masiarz and Bruce A. Malcolm -- 17. Design of Tight-Binding Human Immunodeficiency Virus Type 1 Protease Inhibitors / Joseph P. Vacca -- 18. Design of Symmetry-Based, Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease / Dale J. Kempf -- 19. Advances in Automated Docking Applied to Human Immunodeficiency Virus Type 1 Protease / Michael D. Miller, Robert P. Sheridan, Simon K. Kearsley and Dennis J. Underwood -- 20. Use of Molecular Dynamics and Free Energy Perturbation Calculations in Anti-Human Immunodeficiency Virus Drug Design / Margaret A. McCarrick and Peter Kollman -- 21. Qualitative Study of Drug Resistance in Retroviral Protease Using Structural Modeling and Site-Directed Mutagenesis / J. Chris Culberson, Bruce L. Bush and Vinod V. Sardana.
ISBN
0121821420
OCLC
ocm31189255
Owning Institutions
Columbia University Libraries