Research Catalog

Title

The practice of peptide synthesis / M. Bodanszky, A. Bodanszky.

Author

Bodanszky, Miklos.

Publication

Berlin ; New York : Springer-Verlag, [1994], ©1994.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Bodanszky, A. (Agnes), 1925-

Description

xviii, 217 pages : illustrations; 25 cm.

Summary

The second edition has been completely revised and updated. The book provides examples of practical syntheses of peptides and of reagents needed for peptide synthesis. Technical details and potential hazards receive special attention. Typical syntheses are selected; these can be used when analogous materials have to be prepared. The purpose of the book is to help chemists involved in peptide synthesis with information needed in their work and to absolve them from numerous trips to the library.

Series Statement

Springer lab manual

Uniform Title

Springer lab manual.

Subject

• Peptides > Synthesis

Bibliography (note)

• Includes bibliographical references amd index.

Contents

• I. Introduction -- II. Protecting Groups. 1. Introduction to Amine Protecting Groups -- III. Activation and Coupling. 1. The Acid Chloride Procedure. 2. The Azide Process. 3. Symmetrical Anhydrides. 4. Mixed Anhydrides. 5. Preparation of Active Esters. 6. Coupling with Active Esters. 7. Peptide Bond Formation with the Aid of Coupling Reagents -- IV. Removal of Protecting Groups. 1. Hydrogenation. 2. Reduction with Sodium in Liquid Ammonia. 3. Removal of the Phthalyl (Phthaloyl) Group by Hydrazinolysis Glycyl-glycine. 4. Acidolysis. 5. Hydrolysis. 6. Base Catalyzed Elimination. 7. Nucleophilic Displacement. 8. Iodolysis. 9. Reduction of Methionine Sulfoxide Containing Peptides -- V. Special Procedures. 1. Ammonolysis of Esters. 2. Transesterification. 3. Cyclization. 4. Polycondensation. 5. Partial Synthesis -- VI. Models for the Study of Racemization. 1. Benzoyl-leucyl-glycine Ethyl Ester. 2. The Anderson-Callahan Test. 3. Acylation with Acetyl-L-isoleucine. 4. The Izumiya-Muraoka Model.
• 5. Synthesis and Enantioselective Enzymic Hydrolysis of Tetraalanine -- VII. Reagents for Peptide Synthesis. 1. tert-Butyl Azidoformate. 2. 1-Adamantyl Chlorocarbonate. 3. 1-Isobutyloxycarbonyl-2-isobutyloxy-1,2-dihydroquinoline (IIDQ). 4. Diphenyl Phosphorazidate (Diphenylphosphoryl Azide, DPPA). 5. 3-Hydroxy-3,4-dihydroquinazoline-4-one (4-Hydroxyquinazoline 3-oxide). 6. 1-Hydroxybenzotriazole. 7. Ethyl 2-hydroximino-2-cyanoacetate. 8. 1-Guanyl-3,5-dimethyl-pyrazole Nitrate. 1. Conversion of Dicyclohexylammonium Salts. 2. Preparation of Analytical Samples.

ISBN

• 3540575057 (Berlin : acid-free paper)
• 0387575057 (New York : acid-free paper)

LCCN

94000890

OCLC

• 29843611
• ocm29843611

Owning Institutions

Columbia University Libraries