Research Catalog

Cellular proteolytic systems

Title
Cellular proteolytic systems / editors, Aaron J. Ciechanover, Alan L. Schwartz.
Publication
New York : Wiley-Liss, 1994.

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Additional Authors
  • Ciechanover, Aaron J.
  • Schwartz, Alan L.
Description
x, 233 pages : illustrations; 26 cm.
Summary
  • Within cells, regulation of protein degradation, or proteolysis, is critical to dynamic control of protein levels. Cellular Proteolytic Systems is the first book to provide a detailed and comprehensive summary of advances in the biochemistry, cellular biology, molecular genetics, and physiology of the major proteolytic processes.
  • The field of cellular proteolysis is advancing rapidly and has great potential impact in a variety of research and clinical areas, including AIDS and cancer research and treatment. The editors, pioneers in the field of cellular and protein research, describe our current understanding of the three major cellular proteolytic systems: the ubiquitin system, the lysosomal and vacuolar systems, and physiological and pathophysiological cellular proteolysis.
  • Individual chapters cover topics from the molecular genetics of the ubiquitin system to regulation of autophagy to antigen processing and presentation. Cellular Proteolytic Systems will provide an excellent foundation in the biological basis of protein turnover for cellular, developmental, and molecular biologists.
Series Statement
Modern cell biology ; v. 15
Uniform Title
Modern cell biology ; v. 15.
Subject
  • Proteins > Metabolism
  • Proteolytic enzymes
  • Lysosomes
  • Ubiquitin
  • Proteins > metabolism
  • Lysosomes > physiology
  • Ubiquitin > physiology
  • Metabolism
Note
  • Includes index.
Contents
  • Preface / Aaron J. Ciechanover and Alan L. Schwartz -- The Ubiquitin-Mediated Proteolytic Pathway: Mechanisms of Recognition of the Proteolytic Substrate and Involvement in the Degradation of Native Cellular Proteins / Aaron J. Ciechanover and Alan L. Schwartz -- Molecular Genetics of the Ubiquitin System / David Keith Gonda -- Selective Degradation of Cytosolic Proteins by Lysosomes / J. Fred Dice and Stanley R. Terlecky -- Autophagy: Its Mechanism and Regulation / Glenn E. Mortimore and Motoni Kadowaki -- Hepatic Endosomes Are a Major Physiological Locus of Insulin and Glucagon Degradation In Vivo / Francois Authier, Barry I. Posner and John J. M. Bergeron -- Proteolysis in the Yeast Vacuole / Elizabeth W. Jones and Deborah G. Murdock -- Degradation of Proteins Retained in the Endoplasmic Reticulum / Juan S. Bonifacino and Richard D. Klausner -- Protein Catabolism and Antigen Processing / Clifford V. Harding.
  • Viral Proteases: Structure and Function / Tudor I. Oprea, Chris L. Waller and Garland R. Marshall.
ISBN
047102189X
LCCN
94019184
OCLC
ocm30545966
Owning Institutions
Columbia University Libraries