Research Catalog

Title

Free radicals and oxidation phenomena in biological systems / Marcel Roberfroid, Pedro Buc Calderon.

Author

Roberfroid, M. B.

Publication

New York : M. Dekker, [1995], ©1995.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Buc Calderon, Pedro, 1951-

Description

ix, 272 pages : illustrations; 24 cm

Summary

• Investigating the multiple forms in which radicals participate in living organisms, Free Radicals and Oxidation Phenomena in Biological Systems discusses organic radicals in the metabolism of xenobiotics and endogenous organic radicals as intermediates in cellular metabolism ... explores biomolecular targets for radicals, including proteins, nucleic acids, and unsaturated fatty acyl moieties in lipids ... describes the excessive activation of phagocytes and the irradiation and metabolic activation of chemicals in the pathology of radicals ... examines the mechanism of action and potential clinical applications of antioxidants ... supplies strategies to avoid deleterious effects of mediated free radicals ... and much more.
• This concise reference offers an incomparable analysis of the biological processes mediated by free radicals from a toxicological point of view - explaining in detail the chemistry and biochemistry of all principal types of radicals and providing easy access to information in an integrated, coherent presentation.

Subjects

• Active oxygen > Pathophysiology
• Free radicals (Chemistry) > Pathophysiology
• Oxidation, Physiological

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Ch. I. Definitions, Properties, and Reactions of Radicals. I.1. Definitions and Properties. I.2. Reactions of Radicals. I.3. Properties and Reactions of Radicals: An Overview Emphasizing Biologically Relevant Information -- Ch. II. Biologically Relevant Radicals. II.1. Organic Radicals as Catalytic Intermediates and/or Products of the Metabolism of Xenobiotics. II.2. Endogenous Organic Radicals as Intermediates in Cellular Metabolism. II.3. Biologically Relevant Inorganic Radicals and Related Reactive Molecular Species -- Ch. III. Biomolecular Targets for Radicals and Reactive Oxygen Species. III.1. Small Organic Biomolecules. III.2. Unsaturated Fatty Acyl Moieties in Lipids. III.3. Proteins. III.4. Nucleic Acids. III.5. Radical and Reactive Oxygen Species-Mediated Bioorganic Reactions: A Synthetic Discussion -- Ch. IV. Pathology of Radicals and Reactive Oxygen Species. IV.1. Radicals and Reactive Oxygen Species: Necessary But Dangerous for Aerobic Life.
• IV.2. Irradiation and Metabolic Activation of Chemicals: Two Key Events in Radicals and Reactive Oxygen Species-Mediated Toxicity. IV.3. Excessive Activation of Phagocytic Cells: A Key Event in Radicals and Reactive Oxygen Species-Mediated Pathogenesis -- Ch. V. Antioxidants and Radical Scavengers: Some Therapeutical Uses. V.1. Natural and Synthetic Enzymatic Antioxidants. V.2. Natural and Synthetic Nonenzymatic Antioxidant Molecules -- Ch. VI. Pharmacology of Antioxidant Molecules: Analysis of Their Mechanisms of Action -- VI.1. Introduction. VI.2. Strategies to Prevent Deleterious Free Radical - Mediated Effects.

ISBN

0824795873 (alk. paper)

LCCN

94024926

OCLC

• 31295284
• ocm31295284

Owning Institutions

Columbia University Libraries