Research Catalog

Title

The nature of immunologic tolerance / David W. Scott.

Author

Scott, David W., 1943-

Publication

Austin : R.G. Landes ; Boca Raton, FL : Worldwide distributor, CRC Press, 1994.

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Holdings

Details

Description

116 pages : illustrations; 27 cm.

Series Statement

Medical intelligence unit

Uniform Title

Medical intelligence unit.

Subjects

• Immunological tolerance
• Immune Tolerance
• Immunity, Cellular

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. History: The Early Years of Tolerance. Tolerance Systems Defined -- 2. Properties of the Unresponsive State. The Nature of the Immune Response. Properties of the Unresponsive State -- 3. Systems for Induction of Tolerance: What Do They Tell Us? Sensitivity of the Neonatal Period to Tolerance Induction. Development of T-Cell Tolerance in the Thymus. Differential Properties of T and B Cells in Unresponsiveness. Role of Route of Exposure in Tolerance Induction. Birth, Death and Resurrection of Suppression. T-Cell Tolerance to Model Peptides and Alloantigens -- 4. Mechanisms of T-Cell Tolerance. From 'Horror Autotoxicus' to Clonal Deletion. Clonal Ignorance in the T-Cell Repertoire. Evidence for Deletion in the T-Cell Repertoire. TCR Transgenic Mice Demonstrate Deletion of Specific T Cells. T-Cell Clones Can Be Rendered Anergic by Signal 1 Only. Molecular Pathways of T-Cell Signaling to Anergy. Molecular Events Leading to Apoptosis. Fitting in T-Cell Suppression and Anti-Idiotype Circuits.
• Which Mechanism Where? Central Versus Peripheral Tolerance -- 5. Mechanisms of B-Cell Tolerance. Why Do We Need B-Cell Tolerance? Common Mechanisms for B- and T-Cell Tolerance. Model Systems: Epitope (Hapten) - Specific B-Cell Unresponsiveness. Anti-IgM Serves as a Surrogate for Antigen. Differential Roles of IgM and IgD in B-Cell Signal Transduction. B-Cell Subset Variations in Transgenic Mice. B-Cell Lymphomas as a Model for Tolerance. Molecular Signals for the Induction of Tolerance in B Cells -- 6. Summary: Prospects for Application to Clinical Disease. The Immunologic Misconception of Birth. Dose and Affinity Are Critical for Tolerance Induction. The Route of Antigen Administration Is Critical for Successful Tolerance Induction. Future Therapies Must Consider B- Versus T-Cell Epitopes. Designer Peptides. Modification of Proteins for Reduced Antigenicity and Persistence In Vivo. Lack of Co-stimulation. Fusion Proteins with IgG, with Cytokines, and with Antibodies Targeting Certain Cells.
• Maintenance of Unresponsiveness: Bone Marrow or Peripheral Expression of Tolerogens. Making Choices.

ISBN

1570591008 :

LCCN

94023732

OCLC

• 31435386
• ocm31435386

Owning Institutions

Columbia University Libraries