Research Catalog

Apoptosis and the immune response

Title
Apoptosis and the immune response / editor, Christopher D. Gregory.
Publication
New York : Wiley-Liss, 1995.

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Additional Authors
Gregory, Christopher D.
Description
ix, 416 pages : illustrations; 24 cm
Summary
  • In this timely and important work, an international group of leading investigators takes a close and critical look at programmed cell death and its role in the development, function, and maintenance of the immune system. Along with covering the primary actions of apoptosis, the contributors probe its role in carcinogenesis and HIV-induced pathogenesis.
  • By offering a broad range of views, Apoptosis and the Immune Response presents a current and complete picture of the various aspects and consequences of this phenomenon.
  • Apoptosis and the Immune Response begins with the theories surrounding apoptosis and then covers its basic mechanisms including the morphologic, biochemical, and genetic features. The book offers authoritative discussions on the role of apoptosis in the deletion of self-reactive lymphocytes, prevention of autoimmunity, termination of the immune response, death of T cells infected by the HIV virus, neoplasia, and the homeostatic regulation of the hematopoietic system.
  • With its diverse expertise and timely, clear-cut insights, Apoptosis and the Immune Response will prove to be an invaluable resource for immunologists, cell and developmental biologists, hematologists, and oncologists - as well as graduate students.
Subject
  • Lymphocytes
  • Cell death
  • Apoptosis > immunology
  • Immune System > physiology
Bibliography (note)
  • Includes bibliographical references and index.
Contents
  • Preface / Christopher D. Gregory -- 1. Apoptosis in the Immune System: Concepts and Questions / Gwyn T. Williams -- 2. Apoptosis in Intrathymic T-Cell Development / Pawel Kisielow -- 3. The Regulation of Antigen-Induced Apoptosis in Mature T Lymphocytes / Jeffrey M. Critchfield, Stefen A. Boehme and Michael J. Lenardo -- 4. HIV Infection and T-Cell Death / Jean Claude Ameisen -- 5. Molecular Mechanisms of T-Lymphocyte Cytotoxicity, With Emphasis on the Fas Pathway / Pierre Golstein, Marie-Francoise Luciani, Marie-Genevieve Mattei and Colette Foa -- 6. Fas/APO-1: A Cell Surface Receptor That Signals Apoptosis / Philip L. Cohen and Robert A. Eisenberg -- 7. Apoptosis in Immature B Lymphocytes / David W. Scott -- 8. B-1 Cells (Ly-1 or CD5[superscript +] B Cells), Apoptosis, and Autoimmunity / Takeshi Tsubata -- 9. Control of Apoptosis in Human B Cells: Implications for Neoplasia / Christopher D. Gregory.
  • 10. Signal Transduction Pathways Involved in the Regulation of Survival in Normal and Neoplastic B Lymphocytes / Kirstine A. Knox and John Gordon -- 11. The Innate Immune System: Recognition of Apoptotic Cells / John Savill -- 12. Apoptosis in the Hemopoietic System / Leo Sachs and Joseph Lotem.
ISBN
0471012513
LCCN
94041047
OCLC
ocm31604665
Owning Institutions
Columbia University Libraries