Research Catalog

Title

Genetic analysis : genes, genomes, and networks in Eukaryotes / Philip Meneely.

Author

Meneely, Philip Mark

Publication

• Oxford ; New York, NY : Oxford University Press, [2020]
• ©2020

Items in the Library & Off-site

Holdings

Details

Description

xiv, 474 pages : illustrations (chiefly color); 27 cm

Summary

How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks?With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the interactions of genes during suppression, synthetic enhancement, and epistasis follows, which is then expanded into a consideration of genetic networks and personal genomics. Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight. We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.

Subject

• Genetics
• Genetics > Methodology
• Eukaryotic cells > Research
• Genes
• Genomes
• Genetic Techniques
• Eukaryotic Cells > physiology
• Genomics
• Gene Expression Regulation
• Models, Genetic
• Eukaryoten
• Genanalyse

Bibliography (note)

• Includes bibliographical references and index.

Contents

Unit I: Genes, genomes, and organisms -- The basis for genetic analysis -- Genomes, chromosomes, and epigenetics -- Model organisms and their genomes -- Unit II: Mutants and phenotypes -- Identifying and classifying mutants -- Connecting phenotypes with DNA sequences -- Mutant phenotypes and gene activity -- Reverse genetics: Editing genes in yeast and mice -- Genome editing -- Genome-wide mutant screens -- Unit III: Interactions, pathways, and networks -- Gene interactions: Suppressors and synthetic enhancers -- Epistasis and genetic pathways -- Pathways, networks, and phenotypes.

ISBN

• 0198809905
• 9780198809906

LCCN

99989807236

OCLC

• on1089780007
• 1089780007

Owning Institutions

Columbia University Libraries