Research Catalog

Title

Single-particle cryo-EM of biological macromolecules / edited by Robert M. Glasser, Eva Nogales, Wah Chiu.

Publication

• Bristol, UK : IOP Publishing, [2021]
• © 2021

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Glaeser, Robert M.
• Nogales, Eva
• Chiu, Wah
• Biophysical Society.
• Institute of Physics (Great Britain), publisher.

Description

xix, various pagings : illustrations (some colour); 26 cm.

Summary

"This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data collection, data analysis, and the final validation of results."

Series Statement

Biophysical Society-IOP series

Uniform Title

Biophysical Society-IOP series.

Subject

• Molecular biology
• Macromolecules > Analysis
• Biomolecules > Analysis
• High resolution imaging
• Molecular Biology
• Microscopy, Electron
• Single Molecule Imaging

Bibliography (note)

• Includes bibliographical references.

Audience (note)

• Beginning scientists in academia, pharma, and biotech.

Contents

Introduction and overview -- Sample preparation -- Data collection -- Data processing -- Map validation -- Model building and validation

ISBN

• 0750330376
• 9780750330374
• 9780750330398 (ePub ebook) (canceled/invalid)
• 9780750330381 (Mobipocket ebook) (canceled/invalid)

LCCN

99989807647

OCLC

• on1122732702
• 1122732702

Owning Institutions

Columbia University Libraries