Research Catalog

Title

Peptide-based drug design : controlling transport and metabolism / Michael D. Taylor, Gordon L. Amidon, editors.

Publication

Washington, DC : American Chemical Society, 1995.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Taylor, Mihael D., 1954-
• Amidon, Gordon L.

Description

xviii, 567 pages : illustrations; 26 cm.

Series Statement

ACS professional reference book

Uniform Title

ACS professional reference book.

Subject

• Peptide drugs > Physiological transport
• Peptide drugs > Metabolism
• Peptides > pharmacokinetics
• Drug Design
• Drug Delivery Systems

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Molecular Biology of Amino Acid, Peptide, and Oligopeptide Transport / Rufus M. Williamson and Dale L. Oxender -- 2. Peptide Metabolism at Brush-Border Membranes / Roger H. Erickson -- 3. Peptide Metabolism by Gastric, Pancreatic, and Lysosomal Proteinases / Ramesh Krishnamoorthy and Ashim K. Mitra -- 4. Biopharmaceutical Properties and Pharmacokinetics of Peptide and Protein Drugs / Hye J. Lee -- 5. Intestinal Absorption of [beta]-Lactam Antibiotics / Akira Tsuji -- 6. Oral Absorption of Angiotensin-Converting Enzyme Inhibitors and Peptide Prodrugs / Shiyin Yee and Gordon L. Amidon -- 7. The Intestinal Oligopeptide Transporter: Molecular Characterization and Substrate Specificity / Werner Kramer, Frank Girbig, Ulrike Gutjahr and Simone Kowalewski -- 8. Oral Delivery of Therapeutic Proteins and Peptides by the Vitamin B[subscript 12] Uptake System / Gregory J. Russell-Jones -- 9. Prodrug Approaches for Improving Peptidomimetic Drug Absorption / Barbra H. Stewart and Michael D. Taylor.
• 10. Hepatic Processing of Peptides / David L. Marks, Gregory J. Gores and Nicholas F. LaRusso -- 11. Approaches To Modulating Liver Transport of Peptide Drugs / Mary J. Ruwart -- 12. Blood-Brain Barrier Peptide Transport and Peptide Drug Delivery to the Brain / William M. Pardridge -- 13. Oligopeptide Drug Delivery to the Brain: Importance of Absorptive-Mediated Endocytosis and P-Glycoprotein Associated Active Efflux Transport at the Blood-Brain Barrier / Tetsuya Terasaki and Akira Tsuji -- 14. Molecular Packaging: Peptide Delivery to the Central Nervous System by Sequential Metabolism / Nicholas Bodor and Laszlo Prokai -- 15. Bacterial Peptide Permeases as a Drug Delivery Target / J. W. Payne -- 16. Fungal Peptide Transport as a Drug Delivery System / Jeffrey M. Becker and Fred R. Naider -- 17. Peptidomimetic Design and Chemistry Approaches to Peptide Metabolism / T. K. Sawyer -- 18. Peptide Prodrugs Designed to Limit Metabolism / Judi Moss.
• 19. Improved Duration of Action of Peptide Drugs / John J. Nestor, Jr. -- 20. Cell Culture Models for Examining Peptide Absorption / Donald W. Miller, Akira Kato, Ka-yun Ng, Elsbeth G. Chikhale and Ronald T. Borchardt -- 21. Gastrointestinal Transport of Peptides: Experimental Systems / David Fleisher -- 22. In Vitro Models of Hepatic Uptake: Methods To Determine Kinetic Parameters for Receptor-Mediated Hepatic Uptake / Yuichi Sugiyama and Yukio Kato.

ISBN

0841230587

LCCN

94040969

OCLC

• 31604487
• ocm31604487

Owning Institutions

Columbia University Libraries