Research Catalog

Transacting functions of human retroviruses

Title: Transacting functions of human retroviruses / edited by Irvin S.Y. Chen [and others].
Publication: Berlin ; New York : Springer-Verlag, [1995], ©1995.

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Status	Format	Access	Call Number	Item Location
Request for On-site Use Request Scan How do I pick up this item and when will it be ready?	Text	Request in advance	QR1 .C83 v.193	Off-site

Additional Authors

Chen, Irvin.

Description

vi, 239 pages : illustrations; 25 cm.

Summary

The coding domains of simple retrovirus genomes direct the synthesis of virion proteins. Complex retroviral genomes generate in addition to virion proteins regulatory transacting proteins that are translated from multiple spliced messenger RNAs and fulfill important functions in the virus life cycle. All human retroviruses have such complex genomes.
The transacting proteins of these pathogens are attractive targets for therapeutic intervention because they are viral specific, are essential for efficient virus replication and may be mediators of viral pathogenicity. In summarizing the current knowledge on the regulatory transacting proteins of human retroviruses this volume makes an important contribution toward the control of virus disease.

Series Statement

Current topics in microbiology and immunology, 0070-217X ; v. 193

Uniform Title

Current topics in microbiology and immunology ; 193.

Subjects

Bibliography (note)

Contents

Regulation of Foamy Virus Gene Expression / A. Rethwilm -- Transactivation of Cellular Genes by Human Retroviruses / J. D. Rosenblatt, S. Miles, J. C. Gasson and D. Prager -- Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by the Transactivator Protein Tat / R. B. Gaynor -- HTLV-1 Oncoprotein Tax and Cellular Transcription Factors / M. Yoshida, T. Suzuki, J. Fujisawa and H. Hirai -- The Human Immunodeficiency Virus Type 1 Rev Protein: A Pivotal Protein in the Viral Life Cycle / T. Hope and R. J. Pomerantz -- The Human Immunodeficiency Virus Type 1 Vpu Protein: Roles in Virus Release and CD4 Downregulation / M. Abdul Jabbar -- Viral Protein X / J. C. Kappes -- The Pathogenic Role of Human Immunodeficiency Virus Accessory Genes in Transgenic Mice / B. T. Tinkle, H. Ueda and G. Jay --
The Human Immunodeficiency Virus Type 1 vif Gene: The Road from an Accessory to an Essential Role in Human Immunodeficiency Virus Type 1 Replication / D. J. Volsky, M. J. Potash, M. Simm, P. Sova, X.-Y. Ma, W. Chao and M. Shahabuddin -- Nef / L. Ratner and T. M. J. Niedermann -- The vpr Regulatory Gene of Human Immunodeficiency Virus / D. N. Levy, Y. Refaeli and D. B. Weiner.

ISBN

OCLC

ocm32899681

Owning Institutions

Columbia University Libraries