Research Catalog

Title

Adeno-associated virus (AAV) vectors in gene therapy / edited by K.I. Berns and C. Giraud.

Publication

Berlin ; New York : Springer, [1996], ©1996.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Berns, Kenneth I., 1938-
• Giraud, Catherine.

Description

vi, 173 pages : illustrations; 25 cm.

Summary

• Viral vectors have been the favored delivery vehicle for gene therapy in recent years. Adeno-associated virus has become a candidate of great interest because of its biological properties which include site specific integration in human chromosome 19.
• The subject of this book is the use of adeno-associated virus as a new viral vector for gene therapy. AAV vectors can be used to deliver foreign DNA to mammalian cells with the goal of curing genetic diseases and allied conditions. The non-pathogenicity and site specific integration of AAV via a non-homologous recombination event into human chromosome 19 make this virus a very attractive vector.
• Data from in vitro and in vivo experiments are presented and discussed including recent studies with hematopoietic stem cells and non-dividing cells. Various protocols for preparing recombinant AAV vectors and their intracellular delivery are also extensively discussed. The first trial of AAV as vector for human gene therapy was conducted in late 1995.

Series Statement

Current topics in microbiology and immunology, 0070-217X ; 218

Uniform Title

Current topics in microbiology and immunology ; 218.

Subjects

• Adenoviruses
• Gene therapy

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Biology of Adeno-associated Virus / K. I. Berns and C. Giraud -- The Roles of AAV Rep Proteins in Gene Expression and Targeted Integration / J. A. Chiorini, S. M. Wiener, L. Yang, R. H. Smith, B. Safer, N. P. Kilcoin, Y. Liu, E. Urcelay and R. M. Kotin -- Packaging Systems for Adeno-associated Virus Vectors / J. P. Trempe -- The Challenges of Recombinant Adeno-associated Virus Manufacturing: Alternative Use of Adeno-associated Virus Plasmid/Liposome Complexes for Gene Therapy Applications / J. S. Lebkowski, T. B. Okarma and R. Philip -- Adeno-associated Virus Vectors for Gene Therapy of the Hematopoietic System / S. Chatterjee and K. K. Wong, Jr. -- Adeno-associated Virus Vectors for Gene Transfer into Erythroid Cells / D. M. McCarty and R. J. Samulski -- Adeno-associated Virus 2-Mediated Transduction and Erythroid Lineage-Specific Expression in Human Hematopoietic Progenitor Cells / A. Srivastava, X.-S. Wang, S. Ponnazhagan, S. Z. Zhou and M. C. Yoder --
• Development of Adeno-associated Virus Vectors for Gene Therapy of Cystic Fibrosis / B. J. Carter and T. R. Flotte -- Adeno-associated Virus-Based Vectors As Antivirals / K. K. Wong, Jr. and S. Chatterjee.

ISBN

3540610766

OCLC

ocm35335471

Owning Institutions

Columbia University Libraries