Research Catalog

Title

Bioactive compound design : possibilities for industrial use / edited by M.G. Ford [and others].

Publication

Oxford : Bios Scientific Publishers ; Herndon, VA : Distributor, USA and Canada, BIOS Scientific Publishers, 1996.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Ford, M. G. (Martyn Glenn), 1943-

Description

vii, 186 pages : illustrations

Summary

• The search for novel, biologically active materials is a major goal of many of the biotechnology based industrial companies. These include pharmaceutical, agrochemical and food companies seeking new drugs, pesticides, flavours and aromas. In the past, the process of identifying new compounds has been based on low throughput biological screening of compounds developed and synthesised by organic chemists using traditional procedures.
• Although many valuable products have resulted from this approach, recent developments in information technology, mathematical algorithms and robotics appear to offer alternative approaches which may eventually prove to be more cost-effective. This book describes the impact that these new design procedures are having on the discovery process.

Subjects

• Bioactive compounds > Biotechnology
• Drug Design
• Industrial chemicals
• Biological Factors
• Congress

Genre/Form

Congress.

Note

• Papers presented at a conference held in Potsdam, Sept. 4-7, 1995.

Bibliography (note)

• Includes bibliographical references.

Contents

• Foreword / M. G. Ford -- Computer-aided drug design: facts and fictions / H. Kubinyi -- The use of in vitro and in vivo bioassays to screen for novel agrochemicals: approaches to experimental design / M. R. Bartley and D. Youle -- Screening and rational drug design - competitive or complementary? / R. M. Hyde and A. Hersey -- PASS: Computerized prediction of biological activity spectra for chemical substances / D. A. Filimonov and V. V. Poroikov -- The role of molecular similarity in lead generation / P. M. Dean, M. T. Barakat, S. L. Garland, J. E. J. Mills, T. D. J. Perkins and N. P. Todorov -- Flexible three-dimensional database searching for the identification of novel lead compounds / P. W. Finn and M. Snarey -- The histamine H[subscript 2] receptor as a tool for medicinal chemists / P. H. J. Nederkoorn, G. M. Donne-op den Kelder and H. Timmerman -- Chemometric methods in drug design: tale or tool? / R. Franke --
• Artificial neural networks as an alternative to statistics / D. J. Livingstone and M. G. Ford -- Computer assisted drug design and biotechnology: a case study on lead optimization related to breast cancer therapy / S. Nilsson and U. Norinder -- The role of binding studies in the design of bioactive molecules / K. Shrimanker and N. Sheth -- Non-peptide angiotensin II receptor antagonists: PCA & PLS analyses employing different types of 3D molecular descriptors / M. Mabilia and E. Fioravanzo -- Drug-membrane interaction and accumulation, conformation, efficacy and resistance / J. K. Seydel, E. A. Coats, I. K. Pajeva and M. Wiese -- Physiologic based pharmacokinetic modelling and QSAR / D. E. Leahy, P. A. Arundel, G. E. Blakey and M. Rowland -- Artificial intelligence: the use of computer methods in the prediction of metabolism and toxicity / C. A. Marchant and R. D. Combes -- Environmental early-warning methods for synthesis teams / P. H. Nicholls --
• On the necessity of multivariate statistical tools for modeling biodegradation / J. Devillers.

ISBN

1859961657

LCCN

gb 96046759

OCLC

ocm35713383

Owning Institutions

Columbia University Libraries