Research Catalog

Title

Structure-based drug design / edited by Pandi Veerapandian.

Publication

New York : Marcel Dekker, [1997], ©1997.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Veerapandian, Pandi.

Description

xiii, 647 pages : illustrations; 24 cm

Subject

• Drugs > Design
• Drugs > Structure-activity relationships
• Drugs > Conformation
• Drug Design
• Structure-Activity Relationship

Bibliography (note)

• Includes bibliographical references (p. 620-634) and index.

Contents

• 1. Inhibitors of HIV-1 Protease / Krzysztof Appelt -- 2. Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design / Jianping Ding, Kalyan Das and Prem N. S. Yadav [et al.] -- 3. Retroviral Integrase: Structure as a Foundation for Drug Design / Alison B. Hickman and Fred Dyda -- 4. Bradykinin Receptor Antagonists / Donald J. Kyle -- 5. Design of Purine Nucleoside Phosphorylase Inhibitors / Y. Sudhakara Babu, John A. Montgomery and Charles E. Bugg [et al.] -- 6. Structural Implications in the Design of Matrix-Metalloproteinase Inhibitors / John C. Spurlino -- 7. Structure-Function Relationships in Hydroxysteroid Dehydrogenases / Igor Tsigelny and Michael E. Baker -- 8. Design of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling / Janusz M. Sowadski, Charles A. Ellis and Rolf Karlsson [et al.] -- 9. Structural Studies of Aldose Reductase Inhibition / David K. Wilson, J. Mark Petrash and Florante A. Quiocho --
• 10. Structure-Based Design of Thrombin Inhibitors / Patricia C. Weber and Michael Czarniecki -- 11. Design of Antithrombotic Agents Directed at Factor Xa / William C. Ripka -- 12. Polypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants / Raymond S. Norton -- 13. Rational Design of Renin Inhibitors / V. Dhanaraj and J. B. Cooper -- 14. Structural Aspects in the Inhibitor Design of Catechol O-Methyltransferase / Jukka Vidgren and Martti Ovaska -- 15. Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes / Christopher L. M. J. Verlinde, Hidong Kim and Bradley E. Bernstein [et al.] -- 16. Progress in the Design of Immunomodulators Based on the Structure of Interleukin-1 / Glen Spraggon and Pandi Veerapandian -- 17. Structure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design / Michael A. Jarpe, Carol H. Pontzer and Brian E. Szente [et al.] --
• 18. The Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase / Joseph N. Varghese -- 19. Rhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design / Vincent L. Giranda and Guy D. Diana -- 20. The Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery / Roger Bone and F. Raymond Salemme -- 21. Structure-Based Combinatorial Ligand Design / Amedeo Caflisch and Claus Ehrhardt -- 22. Peptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design / Tomi K. Sawyer.

ISBN

0824798694 (hardcover : alk. paper)

LCCN

97020396

OCLC

• 36884865
• ocm36884865

Owning Institutions

Columbia University Libraries