Research Catalog

Title

The impact of stereochemistry on drug development and use / [edited by] Hassan Y. Aboul-Enein and Irving W. Wainer.

Publication

New York : Wiley, [1997], ©1997.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Aboul-Enein, Hassan Y.
• Wainer, Irving W.

Description

xxvii, 695 pages : illustrations; 24 cm.

Summary

• The book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmarceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops.
• The Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field.

Series Statement

Chemical analysis ; v. 142

Uniform Title

Chemical analysis ; v. 142.

Subject

• Chiral drugs

Note

• Series no. on spine 134 [sic].
• "A Wiley-Interscience publication."

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Ch. 1. Chirality and Drug Hazards / Hassan Y. Aboul-Enein and Laila I. Abou Basha -- Ch. 2. Stereochemistry in the Drug Development Process: Role of Chirality as a Determinant of Drug Action, Metabolism, and Toxicity / Thomas A. Baillie and Kathleen M. Schultz -- Ch. 3. Stereochemical Aspects of Drug Metabolism / Jonathan P. Mason and Andrew J. Hutt -- Ch. 4. Some Examples for Stereoselective Biotransformation of Drugs / Gottfried Blaschke -- Ch. 5. Kinetics of Reactive Phase II Metabolites: Stereochemical Aspects of Formation of Epimeric Acyl Glucoronides and their Reactivity / Hildegard Spahn-Langguth, Leslie Z. Benet and Parnian Zia-Amirhosseini [et al.] -- Ch. 6. Studies on the Stereoselectivity of the Biologically Important Metabolism of Alkene-Alkene Oxide (Oxirane)-Alkanediol / Dorothee Wistuba -- Ch. 7. Chiral Barbiturates: Synthesis, Chromatographic Resolutions, and Biological Activity / Jacek Bojarski --
• Ch. 8. Ethambutol and Tuberculosis, a Neglected and Confused Chiral Puzzle / Bernard Blessington -- Ch. 9. Stereogenic Elements of Pharmaceutical Compounds: Some Aspects on Isomerism, Resolution, and Stereochemical Integrity / Stig G. Allen Mark -- Ch. 10. The Importance of Chiral Separations of Pharmaceuticals / Sut Ahuja -- Ch. 11. Separation of Optically Active Pharmaceuticals Using Capillary Electrophoresis / Timothy J. Ward and Karen D. Ward -- Ch. 12. Chiral Recognition Mechanism of Polysaccharides Chiral Stationary Phases / Eji Yashima and Yoshio Okamoto -- Ch. 13. Micelle-Mediated Capillary Electrophoretic Separation of Enantiomeric Compounds / Michael E. Swartz and Phyllis R. Brown -- Ch. 14. Unified Enantioselective Chromatography Involving Chirasil-Dex / Volker Schurig, Sabine Mayer and Martin Jung [et al.] --
• Ch. 15. Derivatized Cyclodextrins as Chiral Gas Chromatographic Stationary Phases and their Potential Applications in the Pharmaceutical Industry / Weiyong Li and Thomas M. Rossi -- Ch. 16. Chiral Derivatization Reagents in the Bioanalysis of Optically Active Drugs with Chromophore-Based Detection / Ralf Buschges, Hassan Y. Aboul-Enein and Eric Martin [et al.] -- Ch. 17. Circular Dichroism Spectroscopy in the Analysis of Chiral Drugs / Piera Salvadori, Carlo Rosini and Carlo Bertucci -- Ch. 18. Circular Dichroism in the Study of Stereoselective Binding of Drugs to Serum Proteins / Carlo Bertucci, Piero Salvadori and Enrico Domenici -- Ch. 19. Current Regulatory Guidelines of Stereoisomeric Drugs: North American, European, and Japanese Point of View / Sylvie Laganiere -- Ch. 20. Enantioselective Analysis and the Regulation of Chiral Drugs / Michael Gross --
• Ch. 21. First Pass Phenomena: Sources of Stereoselectivities and Variabilities of Concentration-Time Profiles After Oral Dosage / Hildegard Spahn-Langguth, Leslie Z. Benet and Werner Mohrke [et al.] -- Ch. 22. Gastrointestinal Transport Processes: Potentials for Stereoselectivities at Substrate-Specific and Nonspecific Epithelial Transport Systems / Peter Langguth, Gordon L. Amidon and Elke Lipka [et al.] -- Ch. 23. Preparation of Drug Enantiomers by Chromatographic Resolution on Chiral Stationary Phases / Eric Francotte.

ISBN

0471596442 (acid-free paper)

LCCN

96033491

OCLC

• 35262289
• ocm35262289

Owning Institutions

Columbia University Libraries