Research Catalog

Title

The combinatorial index / Barry A. Bunin.

Author

Bunin, Barry A.

Publication

San Diego : Academic Press, [1998], ©1998.

Items in the Library & Off-site

Holdings

Details

Description

xvii, 322 pages : illustrations; 26 cm

Summary

• Combinatorial chemistry has become a major focus of research activity for pharmaceutical, agrochemical, and biotechnology companies. The explosion of combinatorial methods has created the need for a compendium of reliable synthetic transformations from the primary literature. The Combinatorial Index fills this need. Included are chapters on linkers, solid-phase synthetic methods, analytical techniques, and solution libraries.
• Procedures from the literature for constructing combinatorial libraries of small molecules comprise an indispensable laboratory reference for the synthetic chemist. Each procedure in the compilation is preceded by a section entitled "Points of Interest," which highlights the strengths and limitations of the various methods. A structural appendix covers both functional group transformations and heterocyclization reactions in solid-phase synthesis.
• This comprehensive but easy-to-access guide to the combinatorial chemistry literature will save time on tedious library searches, introduce a growing audience of chemists to this exciting field, and lower the barriers to attempting a new or related methodology.

Subject

• Combinatorial chemistry > Handbooks, manuals, etc

Bibliography (note)

• Includes bibliographical references and indexes.

Contents

1. Introduction -- 2. Background -- 3. Linkers for Solid-Phase Synthesis -- 4. Combinatorial Solid-Phase Synthesis -- 5. Analytical Methods for Solid-Phase Synthesis -- 6. Preparation of Solution Libraries and Combined Approaches at the Solution/Solid-Phase Interface -- App. 1. Summary of Functional Group Transformations for Combinatorial Solid-Phase Synthesis -- App. 2. Classification of Heterocyclization Reactions -- App. 3. Unnatural Biopolymers -- App. 4. Oligosaccharides -- App. 5. List of Abbreviations.

ISBN

0121413403

LCCN

97081368

OCLC

ocm38847491

Owning Institutions

Columbia University Libraries