Research Catalog

Title

Molecular diversity and combinatorial chemistry : libraries and drug discovery / Irwin M. Chaiken, Kim D. Janda, [editors].

Publication

Washington, DC : American Chemical Society, [1996], ©1996.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Chaiken, Irwin M.
• Janda, Kim D., 1957-
• Cambridge Healthtech Institute.

Description

ix, 328 pages : illustrations (some color); 24 cm.

Series Statement

Conference proceeding series

Uniform Title

Conference proceedings series (American Chemical Society)

Subjects

• Drugs > Design > Congresses
• Combinatorial chemistry > Congresses

Note

• Proceedings of two conferences sponsored by Cambridge Healthtech Institute held at the Hotel Del Coronado, in Coronado, California, January 28-February 2, 1996.

Bibliography (note)

• Includes bibliographical references and indexes.

Contents

• 1. Secondary Structure Templated Libraries: Mimicking Nature / Maher Qabar, Jan Urban, Charles Sia, Michel Klein and Michael Kahn -- 2. Construct Diversity: A New Paradigm for Combinatorial Chemistry / John C. Roberts, Bert E. Thomas, Yeelana Shen, Anita Melikian-Badalian, Paul J. Kowalczyk and Peter V. Pallai -- 3. Enhancing the Drug Discovery Process by Integration of High-Throughput Chemistry and Structure-Based Drug Design / T. L. Graybill, D. K. Agrafiotis, R. Bone, C. R. Illig, E. P. Jaeger, K. T. Locke, T. Lu, J. M. Salvino, R. M. Soll, J. C. Spurlino, N. Subasinghe, B. E. Tomczuk and F. R. Salemme -- 4. Phosphorus as a Scaffold: Combinatorial Libraries of Non-nucleotide Phosphoramidates / Alan F. Cook and Reza Fathi -- 5. Convergent Solid-Phase Synthesis of Phosphoramidate Combinatorial Libraries / Normand Hebert --
• 6. Solid-Phase Synthesis, Characterization, and Screening of a 43,000-Compound Tetrahydroisoquinoline Combinatorial Library / Michael C. Griffith, Colette T. Dooley, Richard A. Houghten and John S. Kiely -- 7. Solid-Phase and Combinatorial Synthesis of Heterocyclic Scaffolds: Dihydropyridines, Pyridines, and Pyrido [2,3-d]pyrimidines / Dinesh V. Patel, Mikhail F. Gordeev, Bruce P. England and Eric M. Gordon -- 8. Polymer-Supported Chemistry: Synthesis of Small-Ring Heterocycles / A. M. M. Mjalli and B. E. Toyonaga -- 9. A Solution-Phase Strategy for the Parallel Synthesis of Chemical Libraries Containing Small Organic Molecules: A General Dipeptide Mimetic and a Flexible General Template / Christine M. Tarby, Soan Cheng and Dale L. Boger -- 10. Structurally Homogeneous and Heterogeneous Libraries: Scaffold-Based Libraries and Libraries Built Using Bifunctional Building Blocks / Viktor Krchnak, Aleksandra S. Weichsel, Dasha Cabel and Michal Lebl --
• 11. Liquid-Phase Combinatorial Synthesis / Dennis J. Gravert and Kim D. Janda -- 12. Libraries of Transition-Metal Catalysts: High-Throughput Screening of Catalysts for Synthetic Organic Methodology / Kevin Burgess, Destardi Moye-Sherman and Alex M. Porte -- 13. Mixtures of Molecules Versus Mixtures of Pure Compounds on Polymeric Beads / Magda Stankova, Peter Strop, Charlie Chen and Michal Lebl -- 14. Generation of Solution-Phase Libraries of Organic Molecules by Combinatorial Biocatalysis / Yuri L. Khmelnitsky, Peter C. Michels, Jonathan S. Dordick and Douglas S. Clark -- 15. Living Libraries Using Gene Transfer: A Renaissance for Natural Products / K. A. Thompson -- 16. Phage Expression of a De Novo Designed Coiled Coil Stem Loop Miniprotein Scaffold for Constrained Peptide Library Display / Robert M. Miceli, David G. Myszka, Catherine E. Peishoff and Irwin M. Chaiken --
• 17. Automation of High-Throughput Synthesis: Automated Laboratory Workstations Designed To Perform and Support Combinatorial Chemistry / James R. Harness -- 18. Boosting the Productivity of Medicinal Chemistry Through Automation Tools: Novel Technological Developments Enable a Wide Range of Automated Synthetic Procedures / Owen Gooding, Paul D. Hoeprich, Jr., Jeff W. Labadie, John A. Porco, Jr., Paul van Eikeren and Peter Wright -- 19. A Modular System for Combinatorial and Automated Synthesis / S. H. DeWitt, B. R. Bear, J. S. Brussolo, M. J. Duffield, E. M. Hogan, C. E. Kibbey, A. A. MacDonald, D. G. Nickell, R. L. Rhoton and G. A. Robertson -- 20. LiBrain: Software for Automated Design of Exploratory and Targeted Combinatorial Libraries / A. Polinsky, R. D. Feinstein, S. Shi and A. Kuki -- 21. Automation Issues at the Interface Between Combinatorial Chemistry and High-Throughput Screening / Barr E. Bauer --
• 22. Tools for Combinatorial Chemistry / Keith Russell, Derek C. Cole, Frances M. McLaren and Don E. Pivonka -- 23. Magic-Angle Spinning NMR Spectroscopy of Polystyrene-Bound Organic Molecules: Monitoring a Three-Step Solid-Phase Synthesis Involving a Heck Reaction / Christophe Dhalluin, Iuliana Pop, Benoit Deprez, Patricia MeInyk, Andre Tartar and Guy Lippens -- 24. A High-Throughput Functional Assay for G-Protein-Coupled Receptors: Method for Screening Combinatorial Libraries / Christopher J. Molineaux, William Goodwin, Ling Chai, Xiaohua Zhang and David I. Israel -- 25. Use of Combinatorial Libraries in the Discovery and Development of Novel Anti-infectives / Mark A. Wuonola and David G. Powers -- 26. Application of Polymer-Supported Chemistry to the Discovery and Optimization of Lead Drug Candidates / A. L. Harris and B. E. Toyonaga -- 27. Using Pharmacophore Diversity To Select Molecules To Test from Commercial Catalogues / Keith Davies.

ISBN

0841234507 (alk. paper)

LCCN

96020429

OCLC

• 34742361
• ocm34742361

Owning Institutions

Columbia University Libraries