Research Catalog

Approaches to gene mapping in complex human diseases

Title: Approaches to gene mapping in complex human diseases / edited by Jonathan L. Haines, Margaret A. Pericak-Vance.
Publication: New York : Wiley-Liss, [1998], ©1998.

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Status	Format	Access	Call Number	Item Location
Request for On-site Use Request Scan How do I pick up this item and when will it be ready?	Text	Request in advance	RB155.5 .A67 1998	Off-site

Additional Authors

Description

xxii, 434 pages : illustrations; 25 cm

Summary

Approaches to Gene Mapping in Complex Human Diseases is the first book devoted to the analysis of common, inherited diseases. This text helps the reader sort through the plethora of available resources, choose the best methodology for a given problem, and design successful gene mapping projects from the ground up. In eighteen chapters, compiled by two of the leading figures in the field, this book covers a wide range of topics - from the process of selecting families to the testing of candidate genes.
Approaches to Gene Mapping in Complex Human Diseases clearly explains concepts and design procedures while keeping technical details to a minimum. For geneticists, clinicians, molecular biologists, epidemiologists, and anyone interested in the pursuit of genes, it provides a solid grounding in the fundamentals and facilitates a firm grasp of the most advanced procedures and techniques available.

Subjects

Bibliography (note)

Contents

1. Overview of Mapping Common and Genetically Complex Human Disease Traits / Jonathan L. Haines and Margaret A. Pericak-Vance -- 2. Basic Concepts in Genetics / Marcy C. Speer -- 3. Defining Disease Phenotypes / Arthur S. Aylsworth -- 4. Basic Concepts in Linkage Analysis / Margaret A. Pericak-Vance -- 5. Determining the Genetic Component of a Disease / Lindsay A. Farrer and L. Adrienne Cupples -- 6. Patient and Family Participation in Genetic Research Studies / Pamela E. Cohen and Chantelle Wolpert -- 7. Sample Size and Power / Marcy C. Speer -- 8. The Collection of Biological Samples for DNA Analysis / Jeffery M. Vance -- 9. Methods of Genotyping / Jeffery M. Vance and Kamel Ben Othmane -- 10. Database Design for Gene Mapping Studies / Carol Haynes and Colette Blach -- 11. Genomic Screening / Jonathan L. Haines -- 12. Lod Score Analysis / Jianfeng Xu, Deborah A. Meyers and Margaret A. Pericak-Vance -- 13. Sib Pair Analysis / David E. Goldgar --
14. Affected Relative Pair Analysis / Jonathan L. Haines -- 15. Linkage Disequilibrium and Allelic Association / Margaret A. Pericak-Vance -- 16. Using Public Databases / Jonathan L. Haines -- 17. Laboratory Approaches Toward Gene Identification / Douglas A. Marchuk -- 18. Examining Complex Genetic Interactions / Joellen M. Schildkraut -- App. Useful Websites for Genetic Analysis.

ISBN

0471171956 (cloth : alk. paper)

LCCN

97042666

OCLC

ocm37910805

Owning Institutions

Columbia University Libraries