Research Catalog

Title

Polymorphism in pharmaceutical solids / edited by Harry G. Brittain.

Publication

New York : M. Dekker, [1999], ©1999.

Items in the Library & Off-site

Details

Additional Authors

Brittain, H. G.

Description

ix, 427 pages : illustrations; 24 cm.

Summary

• Providing essential information on the myriad physical properties that a single given compound may exhibit, Polymorphism in Pharmaceutical Solids presents a comprehensive examination of polymorphic behavior in pharmaceutical development - demonstrating with clear, practical examples how to navigate complicated crystal structures.
• This superb compendium is essential reading for industrial and product development pharmacists; pharmaceutical scientists; medicinal, physical, surface, colloid, and analytical chemists and spectroscopists; and professional seminars and graduate-level courses in these disciplines.

Series Statement

Drugs and the pharmaceutical sciences ; v. 95

Uniform Title

Drugs and the pharmaceutical sciences ; v. 95.

Subjects

• Hydration
• Molecular Structure
• Crystallization
• Polymorphism (Crystallography)
• Solvation
• Solid dosage forms
• Chemistry, Pharmaceutical

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Theory and Origin of Polymorphism / David J. W. Grant -- 2. Application of the Phase Rule to the Characterization of Polymorphic Systems / Harry G. Brittain -- 3. Structural Aspects of Polymorphism / Harry G. Brittain and Stephen R. Byrn -- 4. Structural Aspects of Hydrates and Solvates / Kenneth R. Morris -- 5. Generation of Polymorphs, Hydrates, Solvates, and Amorphous Solids / J. Keith Guillory -- 6. Methods for the Characterization of Polymorphs and Solvates / Harry G. Brittain -- 7. Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate / Harry G. Brittain and David J. W. Grant -- 8. Effects of Pharmaceutical Processing on Drug Polymorphs and Solvates / Harry G. Brittain and Eugene F. Fiese -- 9. Structural Aspects of Molecular Dissymmetry / Harry G. Brittain -- 10. Impact of Polymorphism on the Quality of Lyophilized Products / Michael J. Pikal.

ISBN

0824702379 (alk. paper)

LCCN

99011315

OCLC

• 40738878
• ocm40738878

Owning Institutions

Columbia University Libraries