Research Catalog

Title

Structure-function analysis of G protein-coupled receptors / edited by Jürgen Wess.

Publication

New York : Wiley-Liss, [1999], ©1999.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Wess, Jürgen, 1956-

Description

xii, 412 pages, 8 unnumbered pages of plates : illustrations (some color); 26 cm.

Summary

• This volume provides a concise, up-to-date presentation of methods (including molecular, genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters.
• Structure-Function Analysis of G Protein-Coupled Receptors is an invaluable reference for receptor biochemists and biological chemists, pharmacologists, and neuroscientists as well as molecular biologists, cell biologists, and structural biologists worldwide.

Series Statement

Receptor biochemistry and methodology

Uniform Title

Receptor biochemistry and methodology.

Subjects

• G proteins > Receptors > Research > Methodology
• Cellular signal transduction > Research > Methodology
• Cell receptors > Research > Methodology

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Overview of Mutagenesis Techniques / Tung Ming Fong -- 2. The Substituted-Cysteine Accessibility Method / Jonathan A. Jovitch -- 3. Using Mutagenesis to Map the Binding Domains of Small Molecule Receptors / Jean E. Lachowicz and Catherine D. Strader -- 4. Mapping Binding Sites for Peptide G Protein-Coupled Receptors: The Receptor for Thyrotropin-Releasing Hormone / Roman Osman, Anny-Odile Colson and Jeffrey H. Perlman / [et al.] -- 5. Lessons From Rhodopsin / Thomas P. Sakmar and K. Christopher Min -- 6. Split Receptors as Tools for Analyzing G Protein-Coupled Receptor Structure / Masahiro Kono and Daniel D. Oprian -- 7. Metal-Ions as Atomic Scale Probes of G Protein-Coupled Receptor Structure / John A. Schetz and David R. Sibley -- 8. Genetic Approaches for Studying the Structure and Function of G Protein-Coupled Receptors in Yeast / Christine M. Sommers and Mark E. Dumont --
• 9. Constitutively Active Receptor Mutants as Probes for Studying the Mechanisms Underlying G Protein-Coupled Receptor Activation / Susanna Cotecchia, Francesca Fanelli and Alexander Scheer / [et al.] -- 10. [beta][subscript 2]-Adrenoceptor-Gs[alpha] Fusion Protein as a Model for the Analysis of Receptor-G Protein Coupling / Roland Seifert and Brian K. Kobilka -- 11. Peptides as Tools for the Study of Receptor-G Protein Interactions / Richard R. Neubig -- 12. Electron-Crystallographic Analysis of Two-Dimensional Rhodopsin Crystals / Gebhard F. X. Schertler -- 13. Site-Directed Spin-Labeling (SDSL) Studies of the G Protein-Coupled Receptor Rhodopsin / David L. Farrens -- 14. Fluorescence Spectroscopy Analysis of Conformational Changes in the [beta][subscript 2]-Adrenergic Receptor / Ulrik Gether -- 15. Biosynthetic Incorporation of Unnatural Amino Acids into G Protein-Coupled Receptors / Andre Chollet and Gerardo Turcatti --
• 16. Use of Nuclear Magnetic Resonance Techniques to Study G Protein-Coupled Receptor Structure / Philip L. Yeagle -- 17. Lead Discovery and Development for G Protein-Coupled Receptors / Dennis J. Underwood and Margaret A. Cascieri.

ISBN

• 047125228X (cloth : alk. paper)
• 0471252271

LCCN

98048496

OCLC

ocm40150649

Owning Institutions

Columbia University Libraries