Research Catalog

Computational analysis of biochemical systems : a practical guide for biochemists and molecular biologists

Title
Computational analysis of biochemical systems : a practical guide for biochemists and molecular biologists / Eberhard O. Voit ; software PLAS by António Ferreira.
Author
Voit, Eberhard O.
Publication
New York : Cambridge University Press, 2000.

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Details

Description
xii, 531 pages : illustrations (some color); 27 cm +
Summary
  • "This book teaches biochemists and molecular biologists in a hands-on fashion the use of modern computational methods for the analysis of complex biomedical systems; a modest mathematical background will suffice. The book begins with representations of biochemical systems, provides guidelines for setting up models, discusses in detail mathematical and computational methods of parameter estimation and model analysis, and ultimately connects to the modern literature with four detailed case studies.
  • Every step is illustrated with examples and exercises, and is explored with the accompanying software, PLAS. A dedicated Web site featuring color illustrations, further exercises, research news, as well as resources and links also accompanies this book."--BOOK JACKET.
Subjects
Bibliography (note)
  • Includes bibliographical references (p. 469-497).
System Details (note)
  • System requirements: Pentium or equivalant processor at 100 MHz or higher; Windows 95, Windows 98, Windows NT 4 or higher, or Windows 2000; 32 MB RAM, 2 MB hard disk space; color monitor with 640 x 480 resolution or higher.
Contents
1. Graphical Representation of Biochemical Systems -- 2. Models of Biochemical Systems -- 3. From Maps to Equations -- 4. Computer Simulation -- 5. Parameter Estimation -- 6. Analytical Steady-State Evaluation -- 7. Sensitivity Analysis -- 8. Case Study 1 - Anaerobic Fermentation Pathway in Saccharomyces cerevisiae -- 9. Case Study 2 - Diagnosis and Refinement of a Model of the Tricarboxylic Acid Cycle in Dictyostelium discoideum -- 10. Case Study 3 - A Sequence of Models Describing Purine Metabolism -- 11. Case Study 4 - Algebraic Analysis of the Initial Steps of the Glycoltic-Glycogenolytic Pathway in Perfused Rat Liver -- 12. Epilogue - Canonical Modeling Beyond Biochemistry.
ISBN
  • 052178087X (hbk.)
  • 0521785790 (pbk.)
LCCN
00021913
OCLC
ocm43333656
Owning Institutions
Columbia University Libraries