Research Catalog

Title

High-throughput synthesis : principles and practices / edited by Irving Sucholeiki.

Publication

New York : Marcel Dekker, [2001], ©2001.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Sucholeiki, Irving, 1963-

Description

xxi, 366 pages : illustrations; 24 cm

Subject

• Combinatorial chemistry

Bibliography (note)

• Includes bibliographical references and indexes.

Contents

• Foreword / Arpad Furka -- Introduction / H. Mario Geysen -- Pt. I. Theory and Methods in Solid Phase Organic Synthesis. Ch. 1. An Introduction to Solid Phase Organic Synthesis / Irving Sucholeiki. Ch. 2. Methods of Analysis to Determine the Progress of a Chemical Reaction on Solid Support / J. Manuel Perez -- Pt. II. High-Throughput Synthesis for Drug Discovery. Ch. 3. High-Throughput Organic Synthesis: A Perspective Looking Back on 10 Years of Combinatorial Chemistry / Michael R. Pavia. Ch. 4. Techniques and Strategies for Producing Compound Libraries for Biological Screening / Stephen R. Wilson and Kathryn Reinhard. Case Study 4-1. A [gamma]-Turn Mimetic Library: Development and Production / Petr Kocis, James B. Campbell and Richard B. Sparks / [et al.]. Case Study 4-2. Production of an [alpha]-Ketoamide-Containing Library via Convergent Parallel Synthesis / Alan P. Kaplan and Carmen M. Baldino.
• Case Study 4-3. Manual Solid Phase Synthesis of a Fully Encoded, 46,656-Member Benzimidazole Library / David Tumelty, Lun-Cong Dong and Kathy Cao / [et al.]. Case Study 4-4. Protease Substrate Specificity Mapping Using Membrane-Bound Peptides / Richard A. Laursen, Caizhi Zhu and Yongjun Duan. Case Study 4-5. Characterization of the Epitope Specificity of Antibodies Using Membrane-Bound Peptides / Richard A. Laursen and Zhengxin Wang. Case Study 4-6. Rapid Parallel Synthesis Utilizing Microwave Irradiation / Brian M. Glass and Andrew P. Combs. Ch. 5. High-Throughput Purification Strategies / Mark J. Suto. Case Study 5-1. Fluorous Scavenging / Bruno Linclau and Dennis P. Curran. Case Study 5-2. Polymer-Assisted Solution Phase Synthesis of [alpha]-Ketoamides / John J. Parlow, Thomas A. Dice and Michael S. South. Case Study 5-3. Ion Exchange Resins for the Preparation of Amide Libraries / Mark J. Suto. Ch. 6. Automating High-Throughput Organic Synthesis / Paul D. Hoeprich, Jr.
• Case Study 6-1. Automated Robotic Parallel Synthesis of a Small-Molecule Library Using Multistep Reactions on Solid Support / Surendrakumar Chaturvedi, Peter V. Fisher and Kenneth M. Otteson / [et al.]. Case Study 6-2. Solid-Phase Parallel Synthesis of Large Tetrahydroisoquinolinone Library / Michal Lebl, Jaylynn C. Pires and Christine Burger / [et al.]. Case Study 6-3. Solid-Phase Parallel Synthesis of a Large Array of Tetrahydroisoquinolinones / Michael Lebl and Jaylynn C. Pires. Case Study 6-4. High-Output Solid-Phase Synthesis of Discrete Compounds Using Directed Split-and-Pool Strategy / Rongshi Li, Xiao-Yi Xiao and K. C. Nicolaou. Case Study 6-5. Multistep Synthesis of 1,2,3-Thiadiazoles Using "Catch and Release" / Yonghan Hu, Sylvie Baudart and John A. Porco, Jr. Case Study 6-6. Automated Multistep Solution Phase Synthesis of Diamines and Allylic Amines / Fariba Aria -- Pt. III. High-Throughput Synthesis of New Materials and Catalysts.
• Ch. 7. Synthesis and High-Throughput Evaluation of Complex Functional Materials Chips / Xiao-Dong Xiang. Case Study 7-1. Studies of Ferroelectric/Dielectric Materials Using Combinatorial Materials Chips / Hauyee Chang and Xiao-Dong Xiang. Case Study 7-2. Synthesis and Evaluation of Thin-Film Dielectrics Using a Composition Spread Approach / R. Bruce van Dover and Lynn F. Schneemeyer. Ch. 8. High-Throughput Screening of Catalyst Libraries / Richard C. Willson, David R. Hill and Phillip R. Gibbs. Case Study 8-1. High-Throughput Screening of Titanium-Tripeptide Schiff Base Complexes for Catalytic Asymmetrical Addition of Trimethylsilylcyanide to Epoxides and Imines / Kevin W. Kuntz, Marc L. Snapper and Amir H. Hoveyda. Case Study 8-2. Selection of Effective Polymer-Bound Acyl Transfer Catalysts by Infrared Thermography / James P. Morken and Steven J. Taylor -- Pt. IV. New Directions in High-Throughput Synthesis.
• Ch. 9. Microfluidic Analysis, Screening, and Synthesis / C. Nicholas Hodge, Luc Bousse and Michael R. Knapp. Ch. 10. Sensors / David R. Walt. Ch. 11. Use of Magnetic Separation Coupled with Power Ultrasound for High-Throughput Solid-Phase Organic Synthesis / Irving Sucholeiki, J. Manuel Perez and Patrick D. Owens.

ISBN

0824702565 (alk. paper)

LCCN

00050928

OCLC

• ocm45248220
• SCSB-4112875

Owning Institutions

Columbia University Libraries