Research Catalog

Title

The calculation of genetic risks : worked examples in DNA diagnostics / Peter J. Bridge.

Author

Bridge, Peter J., 1957-

Publication

Baltimore : Johns Hopkins University Press, [1994], ©1994.

Items in the Library & Off-site

Holdings

Details

Description

xvii, 195 pages : illustrations; 24 cm

Subjects

• Genetic disorders > Risk factors
• Molecular Probe Techniques
• Genetic disorders > Diagnosis
• Diseases > Risk factors
• DNA Probes > diagnostic use
• Health risk assessment
• Genetic Diseases, Inborn > epidemiology
• Genetic Diseases, Inborn > genetics

Bibliography (note)

• Includes bibliographical references (p. [187]-189) and index.

Contents

1. General Introduction to the Estimation of Genetic Risks -- 2. Bayesian Risk Calculations for X-linked Recessive Disorders -- 3. Incorporation of Females with Biochemical Test Results into Bayesian Calculations -- 4. Pedigree Risks in Autosomal Conditions -- 5. Introduction to DNA Polymorphisms -- 6. Statistical Approaches to Gene Mapping -- 7. Use of DNA Polymorphisms in Predicting Genetic Risks -- 8. Integration of RFLP Data with Non-DNA Parameters -- Appendix: Decoding Lod Scores -- Appendix: Pascal's Triangle and the Binomial Expansion -- Appendix: Program to Generate Phase Values for Flanking Markers and Reduced Penetrance or Delayed Age at Onset.

ISBN

0801846781 (hc : alk. paper)

LCCN

93025080

Owning Institutions

Columbia University Libraries