Research Catalog

Title

Antipsychotic drugs and their side-effects / edited by Thomas R. E. Barnes.

Publication

London : Academic Press, [1993], ©1993.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Barnes, Thomas R. E.

Description

xvi, 287 pages; 24 cm

Summary

• .
• However, the introduction of the atypical neuroleptic, clozapine, with a lower liability for motor side-effects, and efficacy for both positive and negative symptoms in patients unresponsive to conventional neuroleptics raised expectations of effective medication with fewer adverse effects. Further, with the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with an inherently better side-effect potential has arisen.
• Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly changing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
• Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including movement disorders like parkinsonism and akathisia; although, in many cases, these can be minimised by titration to the minimum effective dose.
• The advantages and disadvantages of depot preparations and the broad range of potential side-effects are also considered.
• This volume covers both the basic science of neuroleptic drugs and their clinical use. The pharmacology of the conventional and atypical drugs is reviewed, as well as the pharmacokinetics, effects on neuronal and synaptic structure and the contribution of brain imaging techniques to our understanding of the effects of antipsychotic drugs on brain function. The clinical indications for these agents are discussed, as well as their use in both acute and maintenance therapy in psychotic illness.

Uniform Title

Neuroscience perspectives.

Subjects

• Antipsychotic Agents > adverse effects
• Drug-Related Side Effects and Adverse Reactions

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Neuroscience Editorial Advisory Board -- 1. The pharmacology of the phenothiazines, butyrophenones, thioxanthines and diphenylbutylpiperidines / B. E. Leonard -- 2. The pharmacology of clozapine-like atypical antipsychotics / D. M. Coward -- 3. Pharmacology and clinical properties of selective dopamine antagonists with focus on substituted benzamides / Jes Gerlach -- 4. Pre- and postsynaptic D[subscript 1] to D[subscript 5] dopamine receptor mechanisms in relation to antipsychotic activity / John L. Waddington -- 5. Prediction of antipsychotic activity / Nadia M. J. Rupniak and Susan D. Iversen -- 6. Effects of neuroleptics on neuronal and synaptic structure / P. J. Harrison -- 7. Brain imaging and antipsychotic drugs / P. F. Liddle -- 8. Pharmacokinetics of antipsychotic drugs / S. H. Curry -- 9. The assessment of antipsychotic medication in clinical trials / S. R. Hirsch -- 10. Indications for antipsychotic drugs / R. G. McCreadie -- 11. Acute treatment / J. M. Kane.
• 12. Maintenance antipsychotic medication / J. M. Davis, P. G. Janicak, A. Singla and R. P. Sharma -- 13. Depot neuroleptics / D. A. W. Johnson -- 14. The side-effects of antipsychotic drugs. I. CNS and neuromuscular effects / T. R. E. Barnes and J. G. Edwards -- 15. The side-effects of antipsychotic drugs. II. Effects on other physiological systems / J. G. Edwards and T. R. E. Barnes.

ISBN

• 0120790351 :
• 0120790351

LCCN

gb 94009284

Owning Institutions

Columbia University Libraries