Research Catalog

Title

Genes and aging / M.S. Kanungo.

Author

Kanungo, M. S. (Madhu Sudan), 1927-

Publication

Cambridge ; New York, N.Y., USA : Cambridge University Press, c1994.

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Details

Description

xii, 322 p. : ill.; 24 cm.

Summary

• The maximum life span of multicellular organisms varies greatly: for a fruitfly it is about 30 days, for a dog about 20 years, and for a human about 100 years. Despite these differences, all animals show a similar pattern in their life spans - growth, adulthood, and aging, followed by death. The basic cause of aging in multicellular organisms (eukaryotes) lies at the level of the genes, although nutrition and various types of stresses do influence the rate and pattern of aging.
• This book reviews the molecular biology of the gene in relation to aging. Until about a decade ago it was not possible to probe into the types of changes that occur in eukaryotic genes, due to their enormous complexity The use of genetic engineering techniques, however, is beginning to unravel the changes that occur in the genes as an organism ages: such as the changing expression of specific genes under normal conditions and under various types of stress, the changes in the regulatory roles of the sequences in the promoter regions of genes, conformational changes that may occur in genes during aging, and the protein factors that are involved in the aging process.

Subjects

• Eukaryotic Cells > physiology
• Cells > Aging
• Aging > Genetic aspects
• Aging > genetics
• Cellular Senescence

Bibliography (note)

• Includes bibliographical references (p. 290-319) and index.

Contents

1. Introduction -- 2. Phenotypic changes during aging -- 3. Chromatin -- 4. Eukaryotic genes -- 5. Changes in gene expression during aging -- 6. Theories of aging -- 7. Conclusions and future prospects.

ISBN

0521382998

LCCN

93002766

OCLC

• ocm27430412
• SCSB-4724651

Owning Institutions

Columbia University Libraries