Research Catalog

Title

Xenobiotics and inflammation / edited by Lawrence B. Schook, Debra L. Laskin.

Publication

San Diego : Academic Press, [1994], ©1994.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Laskin, Debra L.
• Schook, Lawrence B.

Description

xxi, 361 pages : illustrations; 24 cm

Summary

• Divided into three sections, the book offers an organ system approach to understanding inflammatory and xenobiotics.
• Emphasis is on the roles of cytokines and growth factors in the inflammatory process and how production of these mediators is modified by xenobiotics. Researchers exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites will find this book timely and useful. The editors have brought together experts in inflammation, cytokines, cell growth, immunology, and toxicology to provide a highly useful volume.
• The effect of xenobiotics on general host resistance and on specific immune functions has recently become the focus of much research. Xenobiotics and Inflammation synthesizes current information on how chemicals (xenobiotics) can modulate the immune system, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigating the mechanisms responsibIe for altered host resistance following exposure to xenobiotics.

Subjects

• Growth factors > Pathophysiology
• Immunotoxicology
• Xenobiotics > immunology
• Growth Substances
• Cytokines > Pathophysiology
• Inflammation > Mediators
• Xenobiotics > Immunology

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Immunotoxicity and Inflammation: An Overview / Gary J. Rosenthal and Michael I. Luster -- 2. The Inflammatory Process / Elizabeth J. Kovacs and Michelle R. Frazier-Jessen -- 3. Inflammatory Cytokines: An Overview / Mary E. Brandes and Sharon M. Wahl -- 4. Induction of Inflammation: Cytokines and Acute-Phase Proteins / C.D. Richards and J. Gauldie -- 5. Role of Tumor Necrosis Factor [Alpha] in Acute and Chronic Inflammatory Responses: Novel Therapeutic Approaches / Carl K. Edwards, III, Shawn M. Borcherding, Jun Zhang and David R. Borcherding -- 6. Bone Marrow Phagocytes, Inflammatory Mediators, and Benzene Toxicity / Laureen MacEachern and Debra L. Laskin -- 7. Dimethylnitrosamine-Associated Inflammation: Induction of Cytokines Affecting Macrophage Differentiation and Functions / Lawrence B. Schook, Alice L. Witsell, John F. Lockwood and Michael J. Myers -- 8. Effects of Metals on Lymphocyte Development and Function / Michael J. McCabe, Jr. and David A. Lawrence.
• 9. Xenobiotic-Induced Skin Toxicity / Jeffrey D. Laskin and Diane E. Heck -- 10. Pathogenesis of Atherosclerosis: A Cytokine Hypothesis / George Ku and Richard L. Jackson -- 11. Ozone-Induced Inflammatory Response in Pulmonary Cells / Hillel S. Koren, Robert B. Devlin and Susanne Becker -- 12. Pulmonary Fibrosis Induced by Silica, Asbestos, and Bleomycin / Pierre F. Piguet -- 13. Nonparenchymal Cells, Inflammatory Mediators, and Hepatotoxicity / Debra L. Laskin -- 14. Central Nervous System: Viral Infection and Immune-Mediated Inflammation / Georgia Schuller-Levis, Piotr B. Kozlowski and Richard J. Kascsak.

ISBN

0126289301

LCCN

93048067

Owning Institutions

Columbia University Libraries