Research Catalog

Title

Molecular glycobiology / edited by Minoru Fukuda and Ole Hindsgaul.

Publication

Oxford [England] : IRL Press ; New York : Oxford University Press, [1994], ©1994.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Fukuda, Minoru, 1945-
• Hindsgaul, Ole.

Description

xiii, 261 pages : illustrations; 26 cm.

Summary

• . Molecular Glycobiology is a timely synopsis of this exciting and rapidly expanding field. It provides both an up-to-date description of the subject and leading researchers' views of likely future developments. As such, this volume will be invaluable for active researchers in glycobiology and medicine. However, its easily readable style will also appeal to non-specialists who need an authoritative but accessible text on this subject.
• Cell surface carbohydrates play critical roles in cell-cell interaction. In recent years, major advances have been made in understanding the molecular mechanisms of these processes. Genes encoding glycosyltransferases that synthesize unique oligosaccharides have been isolated, allowing the correlation of specific oligosaccharide structures with function. This book brings together leading researchers to describe our current knowledge in this important area of modern biology.
• Particular emphasis is given to cell-type-specific carbohydrate expression and the carbohydrates and proteins involved in cell recognition. Also included is a full discussion of key experimental approaches such as chemical synthesis and the three-dimensional structural analysis of carbohydrates.

Series Statement

Frontiers in molecular biology

Uniform Title

Frontiers in molecular biology.

Subjects

• Glycoproteins
• Lectins
• Carbohydrates
• Glycolipids

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Cell surface carbohydrates: cell-type specific expression / Minoru Fukuda. 2. Structure of N-glycans. 3. Cell-type specific expression of N-glycans. 4. Mucin-type glycans (O-glycans). 5. [beta]-1,6-N-acetylglucosaminyltransferase. 6. Glycobiology - a new frontier in cell biology and molecular biology -- 2. Molecular structure of animal lectins / Kurt Drickamer. 2. Classification of animal lectins. 3. Lectins containing P-type CRDs: mannose 6-phosphate receptors. 4. Diversity of C-type animal lectins. 5. Soluble [beta]-galactoside-binding (S-type) lectins. 6. Other groups of animal lectins -- 3. Molecular cloning of glycosyltransferase genes / Harry Schachter. 2. Glycosyltransferases. 3. Cloning of glycosyltransferase genes -- 4. Carbohydrate recognition in cell-cell interaction / John B. Lowe. 2. Oligosaccharides in lymphocyte homing. 3. Oligosaccharide-dependent cell adhesion mediated by E-selectin. 4. Oligosaccharide-dependent cell adhesion mediated by P-selectin.
• 5. The sequential, multimolecule model for leukocyte rolling, adhesion, and transmigration -- 5. Chemical synthesis of oligosaccharides / Shaheer H. Khan and Ole Hindsgaul. 2. The problems in oligosaccharide synthesis. 3. Synthesis of acceptor substrates for glycosyltransferases. 4. Inhibitors for glycosyltransferases. 5. Enzyme-assisted oligosaccharide synthesis -- 6. Conformational studies on oligosaccharides / Steven W. Homans. 2. Conformational parameters of oligosaccharides. 3. Sterical structures of oligosaccharides. 4. Dynamics of oligosaccharides. 5. Sterical structure of oligosaccharide-protein complexes. 6. Functional implications.

ISBN

• 0199633878 (h'bk) :
• 019963386X (p'bk) :

LCCN

93041975

Owning Institutions

Columbia University Libraries