Research Catalog

Title

Aqueous two-phase partitioning : physical chemistry and bioanalytical applications / Boris Y. Zaslavsky.

Author

Zaslavsky, Boris Y., 1945-

Publication

New York : M. Dekker, c1995.

Items in the Library & Off-site

Details

Description

xiii, 696 p. : ill.; 24 cm.

Summary

• This useful reference offers in-depth coverage of the fundamental principles of solute partitioning in aqueous two-phase systems, explains their important practical features, and furnishes methods of characterization - examining for the first time in a book of this kind the information provided by the partition behavior of a solute in an aqueous two-phase system.
• Integrating experimental results and theoretical concepts from a wide range of fields such as drug design, bioseparation, physical organic chemistry, and water-soluble polymers, Aqueous Two-Phase Partitioning describes the phase separation of two polymers in an aqueous medium and the role of the solvent in this phenomenon . . . compares the physicochemical properties of the aqueous polymer phases governing solute partitioning with those of water-organic systems . . . supplies a definitive model for the partitioning of solutes in aqueous two-phase systems that accounts for all experimental data available . . . demonstrates the advantages of the partition technique over other methods for studying the hydrophobicity of synthetic and biological substances . . . delineates the role of hydrophobicity as a general structure descriptor in quantitative structure-activity relationship analyses for drugs and biopharmaceuticals . . . gives hands-on recommendations for the development of timesaving analytical and separation procedures using aqueous two-phase systems . . . illustrates new technical applications of the partition technique as a bioanalytical tool for quality control in recombinant products, medical diagnostics, toxicology, and other areas . . . and more.

Subjects

• Biomolecules > Separation
• Chemistry, Physical
• Chromatography, Liquid
• Liquid chromatography

Bibliography (note)

• Includes bibliographical references and index.

Contents

Pt. 1. Phase Separation in Aqueous Polymer Systems. 1. Water in the Presence of Additives. 2. Aqueous Polymer Solutions. 3. Phase Separation in Aqueous Polymer Systems: Experimental Facts and Theoretical Models -- Pt. 2. Partitioning of Solutes in Aqueous Two-Phase Systems. 4. Physicochemical Properties of Phases in Aqueous Polymer Systems. 5. General Trends in Solute Partition Behavior -- Pt. 3. Analytical Applications of the Partition Technique. 6. Hydrophobicity of Biological Solutes: How to Measure It and Its Applications. 7. Measurements of the Relative Hydrophobicity of Biological Solutes by the Aqueous Two-Phase Partition Technique. 8. Analysis of Individual Biopolymers and Their Mixtures. 9. Separation of Biomolecules. 10. Phase Diagrams.

ISBN

0824794613 (acid-free paper)

LCCN

94022868

OCLC

• 30893230
• ocm30893230
• SCSB-4773929

Owning Institutions

Columbia University Libraries