Research Catalog

Title

Camptothecins : new anticancer agents / edited by Milan Potmesil and Herbert Pinedo.

Publication

Boca Raton, FL : CRC Press, c1995.

Items in the Library & Off-site

Details

Additional Authors

• Conference on DNA Topoisomerases in Therapy (4th : 1992 : New York, N.Y.)
• Pinedo, H. M.
• Potmesil, Milan.

Description

149 p. : ill.; 23 cm.

Subject

• Camptothecin > pharmacokinetics
• Camptothecin > pharmacology
• Camptothecin > therapeutic use
• Clinical Trials as Topic
• Neoplasms > drug therapy

Genre/Form

Congress.

Note

• Based on the Fourth Conference on DNA Topoisomerases in Therapy held in New York City in October 1992.

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Introduction / Milan Potmesil and Herbert Pinedo -- Ch. 1. Biochemistry of Camptothecin / Leroy F. Liu -- Ch. 2. Camptothecin and Analogs: From Discovery to Clinic / Monroe E. Wall and Mansukh C. Wani -- Ch. 3. Twenty Years Later: Review of Clinical Trials with Camptothecin Sodium (NSC-100880) / Franco Muggia -- Ch. 4. Preclinical Development of 20 (S)-Camptothecin, 9-Aminocamptothecin and Other Analogs / Milan Potmesil and Beppino C. Giovanella -- Ch. 5. Phase I Clinical Trial and Pharmacokinetic Results with Oral Administration of 20(S)-Camptothecin / John S. Stehlin, Ethan A. Natelson, Hellmuth R. Hinz, Beppino C. Giovanella, Peter D. de Ipolyi, Kim M. Fehir, Thomas P. Trezona, Dana M. Vardeman, Nicholas J. Harris, Alice K. Marcee, Anthony J. Kozielski and Amado Ruiz-Razura -- Ch. 6. Clinical Studies of CPT-11 in Japan / Tetsuo Taguchi.
• Ch. 7. Clinical Trials and Pharmacokinetic Studies of CPT-11 in the United States / Mace L. Rothenberg, Eric K. Rowinsky, John G. Kuhn, Howard A. Burris III, Ross C. Donehower and Daniel D. Von Hoff -- Ch. 8. Clinical Trials and Pharmacology Studies of CPT-11 and its Active Metabolite SN-38 in France: Preliminary Pharmacokinetic-Pharmacodynamic Relationships / Guy G. Chabot, Marcel de Forni, Daniel Abigerges, Jean-Pierre Armand, Michel Clavel, Roland Bugat, Stephane Culine, Jean-Marc Extra, Michel Marty, Marie-Christine Bissery, Anne Mathieu-Boue, Patrice Herait and Alain Gouyette -- Ch. 9. Topotecan Clinical Trials in the United States / Howard Hochster -- Ch. 10. Clinical Trials of Topotecan in Europe / Jaap Verweij, Wim ten Bokkel Huinink, Birthe Lund, Andre Planting, Jos Beijnen, Maureen de Boer-Dennert, Hilde Rosing, Ineke Koier and Heine Hansen -- Ch. 11. Camptothecins: Dose-Limiting Toxicities and Their Management / Howard A. Burris III, Suzanne M. Fields, John G. Kuhn and Daniel D. Van Hoff.
• Ch. 12. Cellular Determinants of Sensitivity and Resistance to Camptothecins / Yves Pommier, Akihiko Tanizawa, Kosuke Okada and Toshiwo Andoh -- Ch. 13. The Perspectives / Milan Potmesil and Herbert Pinedo.

ISBN

0849347645

Owning Institutions

Columbia University Libraries