Research Catalog

Title

Genetic manipulation of the nervous system / edited by D.S. Latchman.

Publication

London ; San Diego : Academic Press, [1996], ©1996.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Latchman, David S.

Description

xvii, 276 pages : illustrations (some color); 24 cm.

Summary

• Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
• The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind.
• Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells.
• In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders.

Series Statement

Neuroscience perspectives

Uniform Title

Neuroscience perspectives.

Subjects

• Humans > Nervous system > Genetic disorders
• Genetic Therapy > methods
• Nervous System Diseases > genetics
• Genetic Engineering
• Neurogenetics

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Genetic manipulation of the nervous system: an overview / D. S. Latchman -- 2. Non-neurotropic adenovirus: a vector for gene transfer to the brain and possible gene therapy of neurological disorders / P. R. Lowenstein, G. W. G. Wilkinson, M. G. Castro, A. F. Shering, A. R. Fooks and D. Bain -- 3. Adenovirus: a new tool to transfer genes into the central nervous system for treatment of neurodegenerative disorders / P. Horellou, F. Revah, O. Sabate, M.-H. Buc-Caron, J.-J. Robert and J. Mallet -- 4. Adenovirus-mediated gene therapy of tumors in the central nervous system / H. D. Shine and S. L. C. Woo -- 5. Gene delivery using adeno-associated virus / L. Tenenbaum and E. L. Hooghe-Peters -- 6. Herpes simplex virus-based vectors / R. S. Coffin and D. S. Latchman -- 7. Gene delivery using herpes simplex virus type 1 plasmid vectors / K. L. O'Malley and A. I. Geller -- 8. Problems in the use of herpes simplex virus as a vector / L. T. Feldman --
• 9. Gene delivery to the nervous system by direct injection of retroviral vector / R. Kageyama, M. Ishibashi and K. Moriyoshi -- 10. Gene delivery to the nervous system using retroviral vectors / M. Sena-Esteves, M. Aghi, P. A. Pechan, E. M. Kaye and X. Breakefield -- 11. Transplantation of genetically modified non-neuronal cells in the central nervous system / M.-C. Senut, S. T. Suhr and F. H. Gage -- 12. Genetic animal models for Alzheimer's disease / R. L. Neve, F. M. Boyce and M. L. Oster-Granite -- 13. Neuronal precursors in the brain of adult mammals: biology and applications / C. Lois and A. Alvarez-Buylla -- 14. Direct injection of plasmid DNA into the brain / M. Tsuda and T. Imaoka -- 15. Antisense oligodeoxynucleotides as novel neuropharmacological tools for selective expression blockade in the brain / M. Helig and K.-H. Schlingensiepen.

ISBN

0124371655

LCCN

gb 96006920

OCLC

• ocm34049369
• SCSB-4779433

Owning Institutions

Columbia University Libraries