Research Catalog

Title

Basic and clinical applications of flow cytometry : proceedings of the 24th Annual Detroit Cancer Symposium, Detroit, Michigan, USA, April 30, May 1 and 2, 1992 / edited by Frederick A. Valeriote, Alexander Nakeff, Manuel Valdivieso.

Author

Detroit Cancer Symposium (24th : 1992)

Publication

Boston : Kluwer Academic Publishers, [1996], ©1996.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Nakeff, Alexander.
• Valdivieso, Manuel.
• Valeriote, Frederick.

Description

ix, 318 pages : illustrations; 24 cm.

Summary

• In the past, both normal hematopoietic tissue and leukemias have been the tissue samples of choice in the application of flow cytometry and some of the most recent applications with these tissues are presented here. However, also discussed are the increasingly sophisticated disaggregation techniques which allow investigators the possibility of training their lasers on solid tumors.
• Not only can we use flow cytometry with associated fluorescent markers to understand the biology of cancer, but also the wide array of existing and developing markers provides us important diagnostic tools in the detection of cancer early in either the malignant or relapse process. The field comes full circle with the use of the technology for gene mapping and other genetic studies to unlock the basic malignant process.
• The focus of Basic and Clinical Applications of Flow Cytometry is on the present and future capabilities of flow cytometry for both medical and biological applications in cancer. This technology began with quite modest instrumentation beginnings with limited capabilities to answer biological questions.
• Today, both the clinical workhorses and the powerful multi-laser, multi-detector, sorting machinery coupled with sophisticated computers and storage devices and the increasing storehouse of markers and dyes are taking us to the limit and beyond in finding answers to the cause and cure of cancer.

Series Statement

Developments in oncology ; 77

Uniform Title

Developments in oncology ; 77.

Subject

• Cancer cells > Identification > Congresses
• Flow Cytometry > methods
• Flow cytometry > Diagnostic use > Congresses
• Neoplasms > pathology

Genre/Form

Congress.

Bibliography (note)

• Includes bibliographical references.

Contents

• 1. Cytometry 2000: Laser Probing the Future / Alexander Nakeff -- 2. Activation and Proliferation of Purified Hematopoietic Precursor Cells from Human Bone Marrow / P. Lansdorp, W. Dragowska and T. Thomas -- 3. Flow Cytometric Proliferative Fraction Analysis in Solid Tumors / Daniel Visscher, Susan M. Wykes and John D. Crissman -- 4. Mitogenic and Non-Mitogenic Induction of Lymphocytic Invasion: Dual Parameter Flow Cytometric Analysis / S. Ratner and D. Lichlyter -- 5. Flow Cytometric Monitoring of Drug Resistance in Human Solid Tumors / Awtar Krishan, Cheppail Ramachandran and Antonieta Sauerteig -- 6. Flow Cytometry in Oncology: Some Lessons from History / Howard M. Shapiro -- 7. DNA Flow Cytometry Application to Clinical Trials in Breast Cancer / Lynn G. Dressler -- 8. Processing of Solid Tumors for DNA Analysis by Flow Cytometry / Charles L. Hitchcock, John F. Ensley and Mark Zalupski --
• 9. SJL Model for Lymphoma Treatment / M. Cankovic, T. Wrone-Smith, E. VanBuren and S. Lerman -- 10. Gene Mapping and Molecular Cytogenetics Using Flow-Sorted Chromosomes / N. P. Carter -- 11. The Clinical Potential of DNA Content Parameters in Human Pediatric and Adult Solid Tumors / Mark Zalupski and John F. Ensley -- 12. Differentiation of Human B-Cell Tumors: A Preclinical Model for Differentiation Therapy / Ayad M. Al-Katib and Ramzi Mohammad -- 13. Probing Immune Responses: The Role of Intracellular Glutathione / Mario Roederer and Leonard A. Herzenberg -- 14. DNA Topoisomerase II Poisons and the Cell Cycle / P. J. Smith -- 15. In Situ Hybridization of Centromeric DNA as Visualized on the Nuclear Matrix by Laser Confocal Cytometry / Kenneth J. Pienta -- 16. Megakaryocytopoiesis 2000 / Alexander Nakeff -- 17. The Molecular Basis for the Control of Mammalian Cell Growth / Gerard I. Evan --
• 18. Isolation of Rare Cells by High-Speed Flow Cytometry and High-Resolution Cell Sorting for Subsequent Molecular Characterization - Application in Prenatal Diagnosis, Breast Cancer and Autologous Bone Marrow Transplantation / James F. Leary, Donald Schmidt, Janet G. Gram, Scott R. McLaughlin, Camille DallaTorre, Stefan Burde and Steven P. Ellis.

ISBN

079233809X (acid-free paper)

LCCN

95039521

Owning Institutions

Columbia University Libraries