Research Catalog

Title

Gene therapy of cancer : translational approaches from preclinical studies to clinical implementation / edited by Edmund C. Lattime [and] Stanton L. Gerson.

Publication

San Diego : Academic Press, [1999], ©1999.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Gerson, Stanton L.
• Lattime, Edmund C., 1951-

Description

xvii, 406 pages, 8 unnumbered pages of plates : illustrations (some color); 29 cm

Summary

• Gene Therapy of Cancer represents a rapidly expanding field translating basic research concepts into new, cutting-edge technological advances. This text provides in-depth coverage of all modalities currently being used by developmental therapists to design new targeted treatments for cancer. The basic biology of cancer and cancer immunology is discussed, as are cancer targets, oncogenes, the cell cycle, induction of apoptosis, drug resistance pathways, and tumor specific antigens.
• Therapeutic approaches include gene replacement therapies, ribozyme and antisense ligonucleotide therapies, retrovirus-mediated gene transfer, adenovirus gene transfer, nonviral approaches, tumor vaccines, engineered immunocompetent cells, and cytokine gene therapy.

Subjects

• Genetic Therapy > methods
• Immunotherapy, Adoptive > methods
• Gene therapy
• Cancer > Immunotherapy
• Cancer > Gene therapy
• Neoplasms > therapy
• Protein Biosynthesis
• Gene Transfer Techniques

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Ch. 1. Tumor Suppressor Genes as Targets for Cancer Gene Therapy / Raymond D. Meng and Wafik S. El-Deiry -- Ch. 2. Characterization of Specific Genetic Alterations in Cancer Cells / Kay Huebner, Teresa Druck and Piotr Hadaczek [et al.] -- Ch. 3. Immunologic Targets for the Gene Therapy of Cancer / Suzanne Ostrand-Rosenberg, Vicky S. Gunther and Todd A. Armstrong [et al.] -- Ch. 4. Retroviral Vector Design for Cancer Gene Therapy / Christopher Baum, Wolfram Ostertag and Carol Stocking [et al.] -- Ch. 5. Non-Infectious Gene Transfer and Expression Systems for Cancer Gene Therapy / Mark J. Cooper -- Ch. 6. Parvovirus Vectors for the Gene Therapy of Cancer / K. K. Wong, Jr., Elizabeth Shaughnessy and Di Lu [et al.] -- Ch. 7. Antibody-Targeted Gene Therapy / A. M. McCall, G. P. Adams and L. M. Weiner -- Ch. 8. The Use of Vaccinia Virus Vectors for Immunotherapy via in Situ Tumor Transfection / Edmund C. Lattime, Laurence C. Eisenlohr and Leonard G. Gomella [et al.] --
• Ch. 9. Ribozymes in Cancer Gene Therapy / Carmela Beger, Martin Kruger and Flossie Wong-Staal -- Ch. 10. In Situ Use of Suicide Genes for Cancer Therapy / Scott M. Freeman, Rajagopal Ramesh and Anupama Munshi [et al.] -- Ch. 11. Transfer of Drug Resistance Genes into Hematopoietic Progenitors / Omer N. Koc, Brian M. Davis and Jane S. Reese [et al.] -- Ch. 12. Cytosine Deaminase as a Suicide Gene in Cancer Gene Therapy / Craig A. Mullen -- Ch. 13. Preemptive and Therapeutic Uses of Suicide Genes for Cancer and Leukemia / Frederick L. Moolten and Paula J. Mroz -- Ch. 14. Antisense Strategies in the Treatment of Leukemias / Bruno Calabretta, Tomasz Skorski and Gerald Zon [et al.] -- Ch. 15. Selectively Replicating Viruses as Therapeutic Agents against Cancer / David Kirn -- Ch. 16. ras Oncogene Products as Tumor-Specific Antigens for Activation of T-Lymphocyte-Mediated Immunity / Scott I. Abrams, J. Andrew Bristol and Jeffrey Schlom --
• Ch. 17. Polynucleotide-Mediated Immunization Therapy of Cancer / Stephen Andrew White, Robert Martin Conry and Theresa V. Strong [et al.] -- Ch. 18. DNA and Dendritic Cell-Based Genetic Immunization against Cancer / Lisa H. Butterfield, Antoni Ribas and James S. Economou -- Ch. 19. Engineering Cellular Cancer Vaccines: Gene and Protein Transfer Options / Mark Tykocinski -- Ch. 20. Cancer Gene Therapy by Direct Transfer of Plasmid DNA in Cationic Lipids / Evan M. Hersh -- Ch. 21. Ex Vivo and in Vivo Cytoreductive Gene Therapy for Urologic Cancers: Translation of Molecular Pharmacology to Clinical Pharmacology / Jonathan W. Simons, Angelo A. Baccala and Yeong Lida -- Ch. 22. Applications of Gene Transfer in the Adoptive Immunotherapy of Cancer / Alfred E. Chang and A. P. Salas -- Ch. 23. Cytokine Gene Therapy of Cancer / Jean-Marie Peron, Michael R. Shurin and Michael T. Lotze --
• Ch. 24. The Use of Genetically Modified Hematopoietic Stem Cells for Cancer Therapy / Lee G. Wilke and James J. Mule -- Ch. 25. Novel Artificial Tumor-Specific Killer Cell and Intrabody Approaches for Cancer Therapy / Si.-Yi Chen.

ISBN

0124371906

Owning Institutions

Columbia University Libraries