Research Catalog

Title

Gene therapy for neurological disorders and brain tumors / edited by E. Antonio Chiocca, Xandra O. Breakefield.

Publication

Totowa, N.J. : Humana Press, [1998], ©1998.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Breakefield, Xandra O.
• Chiocca, E. Antonio.

Description

x, 458 pages : illustrations (some color); 26 cm.

Summary

• Drs. Chiocca and Breakefield bring together in Gene Therapy for Neurological Disorders and Brain Tumors many of the leading gene therapy researchers and clinicians to capture the breadth of the field - from basic vector technology to current and future clinical applications.
• Gene Therapy for Neurological Disorders and Brain Tumors illuminates the rapidly developing applications of gene transfer technologies to the treatment of a wide range of neurological disorders and brain tumors. Readers will learn the current delivery methods for transgenes, will learn the characteristics of the transgene delivery vectors, and come to more fully understand gene therapies for both neuro-oncologic and neurologic disorders.
• The authoritative contributions provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorders, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea.

Series Statement

Contemporary neuroscience

Uniform Title

Contemporary neuroscience.

Subject

• Brain > Gene therapy
• Brain Neoplasms > therapy
• Central Nervous System Diseases > therapy
• Genetic Therapy > methods
• Nervous system > Gene therapy

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Pt. I. Vectors and Promoters -- Vectors for Gene Delivery to the Central Nervous System: An Overview / Joseph Glorioso. 1. Retrovirus Vectors and Regulatable Promoters / Steven A. Reeves. 2. Characteristics of Adenovirus Vectors / Susanna Chiocca and Matt Cotten. 3. HSV Recombinant Vectors: General Characteristics and Potential for Use in the Central Nervous System / Paul A. Johnson. 4. HSV-1 Amplicon / Cornel Fraefel, Xandra O. Breakefield and David R. Jacoby. 5. AAV Vectors: General Characteristics and Potential for Use in the Central Nervous System / Frances I. Smith and Thomas J. McCown. 6. EBV Vectors: General Characteristics and Potential for Gene Therapy in the Central Nervous System / Jean-Michel H. Vos, Keith B. Quattrocchi and Brian J. Wendelburg. 7. Lentiviral Vectors for Gene Delivery in the Central Nervous System / Didier Trono, Ulrike Blomer and Luigi Naldini. 8. Promoters for Expressions of Gene Products Within Neurons and Glia / John W. Henson.
• 9. Immune Response to Viral Vectors / Jason G. Smith and Stephen L. Eck -- Pt. II. Neuro-oncology. 10. Current Treatment Modalities for Brain Tumor: Surgery, Radiation, and Chemotherapy / Stephen B. Tatter and Griffith R. Harsh IV. 11. Experimental and Clinical Gene Therapies for Brain Tumors / E. Antonio Chiocca. 12. Tumor Suppressor Gene Therapy for Brain Tumors / Candelaria Gomez-Manzano, Juan Fueyo and Athanassios P. Kyritsis [et al.]. 13. Cytokine-Based Gene Therapy for Brain Tumors / John H. Sampson, Darell D. Bigner and Glen Dranoff. 14. Delivery of Therapeutic Genes to Brain and Intracerebral Tumors / Leslie L. Muldoon, Robert A. Kroll and Michael A. Pagel [et al.]. 15. Rat Brain Tumor Models and Statistical Evaluation of Survival Data in Experimental Neuro-Oncology / Rolf F. Barth and Melvin L. Moeschberger -- Pt. III. Neurological Disorders -- Neurological Disorders: An Overview / Anne B. Young.
• 16. Gene Transfer for Adult CNS Regeneration and Aging / M. C. Senut, I. Aubert and P. J. Horner [et al.]. 17. Gene Therapy for Parkinson's Disease / Martha C. Bohn and Derek L. Choi-Lundberg. 18. Gene Therapy for Ischemic Stroke / Peter A. Pechan, Masazumi Fujii and Cornell Fraefel [et al.]. 19. Gene Therapy for the Lysomal Storage Diseases / Edward M. Kaye. 20. Gene Therapy for Pain / Gudarz Davar. 21. Gene Therapy of Huntington's Disease / Ole Isaeson and Nadia Haque.

ISBN

0896035077 (acid-free paper)

LCCN

97042613

Owning Institutions

Columbia University Libraries