Research Catalog

Mitochondrial DNA mutations in aging, disease, and cancer

Title
Mitochondrial DNA mutations in aging, disease, and cancer / Keshav K. Singh (Ed.).
Publication
Austin : Landes Bioscience, 1998.

Items in the Library & Off-site

Filter by

1 Item

StatusFormatAccessCall NumberItem Location
Request for On-site UseRequest Scan
How do I pick up this item and when will it be ready?
TextUse in library RB155.5 .M584 1998Off-site

Details

Additional Authors
Singh, Keshav K.
Description
412 p. : ill.; 24 cm.
Summary
  • Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system.
  • Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.
Series Statement
Medical intelligence unit
Uniform Title
Medical intelligence unit.
Subject
  • Mitochondrial DNA > Abnormalities
  • Mitochondrial DNA
  • Mitochondrial pathology
  • Tumors > Genetics
  • DNA, Mitochondrial
  • Mutation
  • Mitochondria > genetics
  • Mitochondria > pathology
  • Aging > genetics
Bibliography (note)
  • Includes bibliographical references and index.
Contents
  • 1. Introduction / Dongchon Kang, Koichiro Takeshige and Mutsuo Sekiguchi [et al.] -- 2. Mitochondrial Structure, Function and Biogenesis / Alfred S. Lewin -- 3. The Mitochondrial Genetic System / Howard T. Jacobs and Ian J. Holt -- 4. Inheritance of Mitochondrial Mutations / C. William Birky, Jr. -- 5. Mitochondrial DNA Replication / Kylie F. Keshav and Shonen Yoshida -- 6. Genetic Integrity of the Mitochondrial Genome / Lene Juel Rasmussen and Keshav K. Singh -- 7. Modeling Mitochondrial DNA Mutations / T. B. L. Kirkwood and A. Kowald -- 8. Mitochondrial Regulation of Apoptosis / Patrice X. Petit and Guido Kroemer -- 9. Characteristics of Mitochondrial DNA Diseases / Carlos T. Moraes -- 10. Nuclear Defects Affecting Mitochondrial Function / Brian H. Robinson -- 11. Mitochondrial DNA Mutations in Aging / Phillip Nagley and Chunfang Zhang -- 12. Mitochondrial DNA Mutations and Heart Disease / Takayuki Ozawa and Mika Hayakawa --
  • 13. Mitochondrial Dysfunction and Neurodegenerative Diseases / Michael Lin and M. Flint Beal -- 14. Toxin Induced Mitochondrial Dysfunction and Neurodegeneration / Mohammad I. Sabri -- 15. Perspectives on Mitochondria in Carcinogenesis / Brian Bandy and Allan J. Davison -- 16. The Mitochondrion as a Target for Cancer Chemotherapy / Josephine S. Modica-Napolitano -- 17. Prohibitin: Mitochondrial Tumor Suppressor Protein / J. Keith McClung -- 18. Abnormal Growth and Male Sterility Associated with Mitochondrial DNA Rearrangements in Plants / Kathleen J. Newton and Susan J. Gabay-Laughnan -- 19. Mitochondrial Disorder and Migraine / K. M. A. Welch and Charles Flippen -- 20. Gene Therapy of Mitochondrial DNA Diseases / Peter Seibel, Adrian Flierl and Corinna Bachmann [et al.].
ISBN
3540643427
LCCN
97050433
OCLC
  • 224276571
  • ocn224276571
  • SCSB-4786379
Owning Institutions
Columbia University Libraries