Research Catalog

Title

Biophysics of computation : information processing in single neurons / Christof Koch.

Author

Koch, Christof

Publication

New York : Oxford University Press, 1999.

Items in the Library & Off-site

Details

Description

xxiii, 562 p. : ill.; 25 cm.

Summary

• Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons.
• The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.
• Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.

Series Statement

Computational neuroscience

Uniform Title

Computational neuroscience.

Subject

• Computational neuroscience
• Neurons
• Neural networks (Neurobiology)
• Action potentials (Electrophysiology)
• Neural conduction
• Nerve Net
• Action Potentials
• Neural Conduction

Bibliography (note)

• Includes bibliographical references (p. 503-552) and index.

Contents

• 1. The Membrane Equation -- 2. Linear Cable Theory -- 3. Passive Dendritic Trees -- 4. Synaptic Input -- 5. Synaptic Interactions in a Passive Dendritic Tree -- 6. The Hodgkin - Huxley Model of Action Potential Generation -- 7. Phase Space Analysis of Neuronal Excitability -- 8. Ionic Channels -- 9. Beyond Hodgkin and Huxley: Calcium and Calcium-Dependent Potassium Currents -- 10. Linearizing Voltage-Dependent Currents -- 11. Diffusion, Buffering, and Binding -- 12. Dendritic Spines -- 13. Synaptic Plasticity -- 14. Simplified Models of Individual Neurons -- 15. Stochastic Models of Single Cells -- 16. Bursting Cells -- 17. Input Resistance, Time Constants, and Spike Initiation -- 18. Synaptic Input to a Passive Tree -- 19. Voltage-Dependent Events in the Dendritic Tree -- 20. Unconventional Computing -- 21. Computing with Neurons: A Summary -- App. A. Passive Membrane Parameters -- App. B. A Miniprimer on Linear Systems Analysis --
• App. C. Sparse Matrix Methods for Modeling Single Neurons.

ISBN

0195104919 (alk. paper)

LCCN

97051390

OCLC

• 38130648
• ocm38130648
• SCSB-4786575

Owning Institutions

Columbia University Libraries