Research Catalog

Title

Mouse genetics and transgenics : a practical approach / edited by Ian J. Jackson and Catherine M. Abbott.

Publication

New York : Oxford University Press, 2000.

Items in the Library & Off-site

Details

Additional Authors

Smith, Christopher W. J.

Description

xxiv, 299 p. : ill.; 24 cm.

Summary

"Mouse Genetics and Transgenics: A Practical Approach is set to become a classic laboratory guide to the mouse. All major aspects are covered including: care and husbandry; archiving stocks as frozen embryos or sperm; mapping mutations and phenotypic trait loci; genetic and physical mapping of genomes; mouse cytogenetics and FISH; making new mutations by chemical mutagenesis or by directed mutagenesis through targeting in ES cells; making transgenic mice from plasmids, BACs and YACs; spatial analysis of gene expression. Details of the many databases for mouse researchers are also included together with specific guidance on information gathering and dissemination via the Internet." "This book will be an invaluable laboratory companion for every mouse researcher and for human geneticists who want to turn to the mouse model to address problems of human disease."--BOOK JACKET.

Series Statement

The practical approach series ; 217

Uniform Title

Practical approach series ; 217.

Subjects

• Inbreeding
• Laboratory Manual
• Mice > Breeding > Laboratory manuals
• Mice > genetics
• Transgenic mice > Laboratory manuals
• Mice, Transgenic
• Mice as laboratory animals > Laboratory manuals
• Mice > Genetics > Laboratory manuals
• Animals, Laboratory

Genre/Form

Laboratory Manual.

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Mouse care and husbandry / Colin M. Hetherington, Brendan Doe and Donald Hay -- 2. Cryopreservation and rederivation of embryos and gametes / Peter H. Glenister and William F. Rall -- 3. Spatial analysis of gene expression / Stefan G. Nonchev and Mark K. Maconochie -- 4. Mapping phenotypic trait loci / Benjamin A. Taylor -- 5. Mapping genomes / Paul Denny and Stephen D. M. Brown -- 6. Mouse cytogenetics and FISH -- 7. Electronic tools for accessing the mouse genome / Janan T. Eppig -- 8. Mutagenesis of the mouse germline / Monica J. Justice -- 9. Generation of transgenic mice from plasmids, BACs and YACs / Annette Hammes and Andreas Schedl -- 10. Directed mutagenesis in embryonic stem cells / Antonius Plagge, Gavin Kelsey and Nicholas D. Allen.

ISBN

• 0199637091 (hardcover)
• 0199637083 (pbk.)

LCCN

99037591

Owning Institutions

Columbia University Libraries