Research Catalog

Glutamine repeats and neurodegenerative diseases : molecular aspects / edited by Peter Harper and Max Perutz.

Title
Glutamine repeats and neurodegenerative diseases : molecular aspects / edited by Peter Harper and Max Perutz.
Publication
New York : Oxford University Press, 2001.

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TextRequest in advance RC365 .G58 2001Off-site

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Details

Additional Authors
  • Harper, Peter S.
  • Perutz, Max F.
Description
xvii, 312 pages, 8 unnumbered pages of color plates : illustrations; 24 cm
Subject
  • Glutamine > Pathophysiology
  • Glutamine
  • Huntington Disease
  • Nervous system > Genetic aspects
  • Nervous system > Molecular aspects
  • Neurodegenerative Diseases > genetics
Note
  • "Edited and updated compilation evolving from a Royal Society discussion meeting"--Cover p. 4.
Bibliography (note)
  • Includes bibliographical references and index.
Contents
  • 1. Huntington's disease: a clinical, genetic and molecular model for polyglutamine repeat disorders / P. S. Harper -- 2. A transgenic mouse model of Huntington's disease / L. Mangiarini, K. Sathasivian and A. Mahal / [et al.] -- 3. From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease / S. W. Davies, M. Turmaine and B. A. Cozens / [et al.] -- 4. Behavioural changes and selective neuronal loss in full-length transgenic mouse models for Huntington's disease / P. H. Reddy, V. Charles and W. O. Whetsell / [et al.] -- 5. Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin / A. S. Hackam, J. G. Hodgson and R. Singaraja / [et al.] -- 6. A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster / N. M. Bonini --
  • 7. Polyglutamine pathogenesis, potential role of protein interactions, proteolytic processing and nuclear localization / C. A. Ross, J. D. Wood and M. F. Peters / [et al.] -- 8. Properties of polyglutamine expansion in vitro and in a cellular model for Huntington's disease / A. Lunkes, Y. Trottier and J. Fagart / [et al.] -- 9. Evidence for a recruitment and sequestration mechanism in Huntington's disease / E. Preisinger, B. M. Jordan and A. Kazantsev / [et al.] -- 10. Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats / B. Hollenbach, E. Scherzinger and K. Schweiger / [et al.] -- 11. The localization and interactions of huntingtin / A. L. Jones --
  • 12. Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brain / J. C. Dorsman, M. A. Smoor and M. L. C. Maat-Schieman / [et al.] -- 13. Are there multiple pathways in the pathogenesis of Huntington's disease? / N. Aronin, M. Kim and G. Laforet / [et al.] -- 14. CAG repeat instability, cryptic sequence variation and pathogenicity: evidence from different loci / M. Frontali, A. Novelletto and G. Annesi / [et al.] -- 15. Microsatellite and trinucleotide repeat evolution: evidence for mutational bias and different rates of evolution in different lineages / D. C. Rubinsztein, B. Amos and G. Cooper -- 16. Genotype-phenotype correlation in the spinocerebellar ataxias / P. F. Worth, A. Brice and N. W. Wood --
  • 17. Insights from mice carrying X-linked CAG-polyglutamine-repeat mutations / J. M. Ordway, J. A. Cearley and P. J. Detloff -- 18. Molecular pathology of dentatorubral-pallidoluysian atrophy / Ichiro Kanazawa -- 19. Androgen receptor mutation in Kennedy's disease / K. H. Fishbeck, A. Lieberman and C. K. Bailey / [et al.] -- 20. Progress in pathogenesis studies of spinocerebellar ataxia type 1 / C. J. Cummings, H. T. Orr and H. Y. Zoghbi -- 21. Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and [alpla]-synucleinopathies / Michael Goedert.
ISBN
0198506856
LCCN
00053084
Owning Institutions
Columbia University Libraries