Research Catalog
Handbook of nucleoside synthesis / Helmut Vorbrüggen, Carmen Ruh-Pohlenz.
- Title
- Handbook of nucleoside synthesis / Helmut Vorbrüggen, Carmen Ruh-Pohlenz.
- Author
- Vorbrüggen, Helmut.
- Publication
- New York : Wiley, 2001.
Items in the Library & Off-site
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1 Item
| Status | Format | Access | Call Number | Item Location |
|---|---|---|---|---|
| Text | Request in advance | QP625.N88 V67 2001 | Off-site |
Details
- Additional Authors
- Ruh-Pohlenz, Carmen.
- Description
- xii, 631 p. : chiefly ill.; 23 cm.
- Subjects
- Genre/Form
- Handbook.
- Bibliography (note)
- Includes bibliographical references (p. 590-628) and index.
- Contents
- Nucleoside Synthesis. The Fusion Reaction. The Metal Salt Procedure. The Classical Hilbert-Johnson Procedure for the Preparation of Pyrimidine Nucleosides. The Silyl-Hilbert-Johnson Reaction -- Silyl-Hilbert-Johnson Reaction in the Presence of Friedel Crafts Catalysts. Nucleoside Synthesis with SnCl and Related Friedel-Crafts Catalysts. Nucleoside Formation with Trimethylsilyl Triflate. Transglycosylation with Lewis Acids. One Step-One Pot Nucleoside Syntheses -- Mechanism of Nucleoside Formation in the Presence of Friedel Crafts Catalysts. Experimental Results. Reversible [sigma]-Complex Formation between Silylated Bases and Friedel-Crafts Catalysts. Mechanism of Pyrimidine and Purine Nucleoside Synthesis. Regioselectivity of Nucleoside Formation -- Special Preparations. Synthesis of 2'-Deoxynucleosides. Chemical Conversion of Ribo-to 2'-Deoxyribonucleosides. Synthesis of [beta]-D-Arabinofuranosylpyrimidine and Purine Nucleosides -- Miscellaneous Methods.
- Alternative Silyl-Hilbert-Johnson Procedures. Catalysis by Alkali Halides. Activation of I-Sulfur Groups. Alternative Formation of I-Sugar Cations. Variations of the Hilbert-Johnson Reaction -- Alternative Nucleoside-Forming Reactions. Nucleoside Synthesis with Protected I-Hydroxysugars. Construction of the Heterocyclic Base to Unsaturated Systems. Conjugate Addition of Heterocyclic Bases to Unsaturated Systems. Enzymatic Transglycosylations -- Experimental Conditions. Sugar Moieties. Heterocycles. Silylation. Friedel-Crafts Catalysts. Solvents. Workup of Friedel-Crafts-Catalyzed Silyl-Hilbert-Johnson Reactions. Removal of O-Acyl, N-Acyl, O-Benzyl, or O-Silyl Protecting Groups. Melting Points of Free Nucleosides -- Experimental Procedures -- Tabular Survey.
- ISBN
- 0471093831 (paper)
- LCCN
- 2001024557
- Owning Institutions
- Columbia University Libraries