Research Catalog

Computational molecular biology : an introduction / Peter Clote, Rolf Backofen.

Title
Computational molecular biology : an introduction / Peter Clote, Rolf Backofen.
Author
Clote, Peter.
Publication
New York : John Wiley, 2000.

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Details

Additional Authors
Backofen, Rolf.
Description
ix, 286 pages : illustrations; 25 cm.
Summary
"Primarily aimed at advanced undergraduate and graduate students from bioinformatics, computer science, statistics, mathematics and the biological sciences, this text will also interest researchers from these fields."--BOOK JACKET.
Series Statement
Wiley series in mathematical and computational biology
Uniform Title
Wiley series in mathematical and computational biology.
Subjects
Bibliography (note)
  • Includes bibliographical references (p. ).
Contents
  • 1. Molecular Biology. 1.1. Some Organic Chemistry. 1.2. Small Molecules. 1.3. Sugars. 1.4. Nucleic Acids. 1.5. Proteins. 1.6. From DNA to Proteins. 1.7. Exercises -- 2. Math Primer. 2.1. Probability. 2.2. Combinatorial Optimization. 2.3. Entropy and Applications to Molecular Biology. 2.4. Exercises. 2.5. Appendix: Modification of Bezout's Lemma -- 3. Sequence Alignment. 3.1. Motivating Example. 3.2. Scoring Matrices. 3.3. Global Pairwise Sequence Alignment. 3.4. Multiple Sequence Alignment. 3.5. Genomic Rearrangements. 3.6. Locating Cryptogenes and Guide RNA. 3.7. Expected Length of gRNA in Trypanosomes. 3.8. Exercises. 3.9. Appendix: Maximum-Likelihood Estimation for Pair Probabilities -- 4. All About Eve. 4.1. Introduction. 4.2. Rate of Evolutionary Change. 4.3. Clustering Methods. 4.4. Maximum Likelihood. 4.5. Quartet Puzzling. 4.6. Exercises -- 5. Hidden Markov Models. 5.1. Likelihood and Scoring a Model.
  • 5.2. Re-estimation of Parameters. 5.3. Applications. 5.4. Exercises -- 6. Structure Prediction. 6.1. RNA Secondary Structure. 6.2. DNA Strand Separation. 6.3. Amino Acid Pair Potentials. 6.4. Lattice Models of Proteins. 6.5. Hart and Istrial's Approximation Algorithm. 6.6. Constraint-Based Structure Prediction. 6.7. Protein Threading. 6.8. Exercises.
ISBN
  • 0471872512 (alk. paper)
  • 0471872520 (pbk. : alk. paper)
LCCN
00038169
Owning Institutions
Columbia University Libraries