Research Catalog

Title

Handbook of comparative genomics : principles and methodology / Cecilia Saccone, Graziano Pesole.

Author

Saccone, C.

Publication

New York : Wiley-Liss, c2003.

Items in the Library & Off-site

Details

Additional Authors

Pesole, Graziano

Description

xiv, 427 p. : ill.; 26 cm.

Subjects

• Evolution, Molecular
• Genomics > Handbooks, manuals, etc
• Evolutionary genetics > Handbooks, manuals, etc
• Computational Biology
• Sequence Analysis, DNA

Bibliography (note)

• Includes bibliographical references (p. 377-422) and index.

Contents

• I. Genome Features -- 1. Prokaryotes -- Morphology and Classification -- Genome Shape and Size -- Gene Content and Organization -- Base Composition -- Codon Use -- Replication and Expression -- 2. Eukaryotes -- Classification and Time Scale -- Genome Shape and Size -- Base Composition -- Replication, Repair, and Recombination -- Gene Expression -- Completely Sequenced Eukaryotic Genomes -- 3. Organelles -- Mitochondria -- Chloroplasts and Other Plastids -- II. Methodologies -- 4. Molecular Biology Techniques for Genomics -- Genome DNA Sequencing -- Analysis of the Transcriptome -- Analysis of the Proteome -- 5. Biological Databases in the Genomic ERA -- Primary and Specialized Databases -- Database Structures -- Linked Databases and Database Interoperability -- Database Annotation -- Retrieval Systems -- Nucleotide Databases -- Protein Databases -- Other Protein Databases -- Genomic Databases and Resources --
• Gene Databases and Resources -- Transcriptome Databases -- Metabolism Databases -- Mutation Databases -- Mitochondrial Databases and Resources -- 6. Computational Methods for the Analysis of Genome Sequence Data -- Dot-Plot Matrix -- Sequence Pairwise Alignment -- Database Searching -- Multiple Alignment -- Alignment Profiles to Recognize Distantly Related Protein or Protein Modules -- Methods for Sequence Assembly -- Linguistic Analysis of Biosequences -- Prediction of RNA Secondary Structures -- Protein Sequence Analysis -- Evolutionary and Phylogenetic Analysis -- III. Comparative Genomics -- 7. Molecular Evolution -- Evolution of Genome Size -- Role of Base Composition in Evolution -- Evolution of the Prokaryotic Genome -- From Prokaryotes to Eukaryotes -- From Unicellular to Multicellular State -- Evolution of the Nuclear Genome -- 8. Molecular Phylogeny -- Molecular Clock -- Similarity Measure: Orthology Versus Paralogy --
• Molecular Phylogeny in the Genomics Era -- Interrelationships between Distant Taxa: The Tree of Life -- Phylogeny of Metazoans -- App. URLs Cited in the Text.

ISBN

047139128X (cloth : alk. paper)

LCCN

2002011158

OCLC

• ocm50198292
• SCSB-4795921

Owning Institutions

Columbia University Libraries