Research Catalog

Title

Multiple analyses in clinical trials : fundamentals for investigators / Lemuel A. Moyé.

Author

Moyé, Lemuel A.

Publication

New York : Springer-Verlag, c2003.

Items in the Library & Off-site

Details

Description

xxiii, 436 p. : ill.; 24 cm.

Summary

"Multiple Analyses in Clinical Trials: Fundamentals for Investigators is an essentially nonmathematical discussion of the problems posed by the execution of multiple analyses in clinical trials. It concentrates on the rationale for the analyses, the difficulties posed by their interpretation, easily understood solutions, and useful problem sets. This text will help clinical investigators understand multiple analysis procedures and the key issues when designing their own work or reviewing the research of others. This book is written for advanced medical students, clinical investigators at all levels, research groups within the pharmaceutical industry, regulators at the local, state, and federal levels, and biostaticians. Only a basic background in health care and introductory statistics is required."--BOOK JACKET.

Series Statement

Statistics for biology and health

Uniform Title

Statistics for biology and health.

Subject

• Clinical trials
• Multivariate analysis
• Clinical trials > Statistical methods
• Clinical Trials as Topic
• Multivariate Analysis
• Statistics as Topic

Bibliography (note)

• Includes bibliographical references and index.

Contents

Ch. 1. Fundamentals of Clinical Trial Design -- Ch. 2. Multiple Analyses and the Random Experiment -- Ch. 3. The Lure and Complexity of Multiple Analyses -- Ch. 4. Multiple Analyses and Multiple Endpoints -- Ch. 5. Introduction to Multiple Dependent Analyses I -- Ch. 6. Multiple Dependent Analyses II -- Ch. 7. Introduction to Composite Endpoints -- Ch. 8. Multiple Analyses and Composite Endpoints -- Ch. 9. Introduction to Subgroup Analyses -- Ch. 10. Subgroups II: Effect Domination and Controversy -- Ch. 11. Subgroups III: Confirmatory Analyses -- Ch. 12. Multiple Analyses and Multiple Treatment Arms -- Ch. 13. Combining Multiple Analyses -- Ch. 14. Conclusions: The Two-Front War -- App. A. Case Reports and Causality -- App. B. Estimation in Random Research -- App. C. Relevant Code of Federal Regulations -- App. D. Sample Size Primer -- App. E. Additional Dependent Hypothesis Testing Results.

ISBN

038700727X (hc. : alk. paper)

LCCN

2003044598

OCLC

• ocm51839155
• SCSB-4819211

Owning Institutions

Columbia University Libraries